Sugar addiction: An Achilles’ heel of auto-immune diseases?

Dietmar M.W. Zaiss, Paul J. Coffer*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

Abstract / Description of output

In this issue of Cell Metabolism, Hochrein et al. identify a metabolic checkpoint controlling the transcriptional programming of effector CD4+ T cells. The authors show that GLUT3-mediated glucose import and ACLY-dependent acetyl-CoA generation control histone acetylation and, hence, the epigenetic imprinting of effector gene expression in differentiated effector CD4+ T cells. These findings suggest a novel therapeutic target for inflammation-associated diseases.

Original languageEnglish
Pages (from-to)503-505
Number of pages3
JournalCell Metabolism
Issue number4
Publication statusPublished - 5 Apr 2022


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