Supersaturation dependence of glycine polymorphism using laser-induced nucleation, sonocrystallization and nucleation by mechanical shock

Yao Liu, Mees H. Van Den Berg, Andrew J. Alexander

Research output: Contribution to journalArticlepeer-review

Abstract

The nucleation of glycine from aqueous supersaturated solution has been studied using non-photochemical laser-induced nucleation (NPLIN), ultrasound (sonocrystallization), and mechanical shock of sample vials. It was found that at higher supersaturation, samples were more susceptible to nucleation and produced more of the -glycine polymorph. The results are described in terms of a mechanism common to all three nucleation methods, involving the induction of cavitation events and pressure shockwaves. The switch in
preference from - to -glycine was observed to occur over a narrower range of
supersaturation values for NPLIN. We attribute this to induction of cavitation events with higher energies, which result in higher localized pressures and supersaturations. Experiments on NPLIN using circularly versus linearly polarized light showed no evidence for binary polarization switching control of glycine polymorphism.
Original languageEnglish
Pages (from-to)19386-19392
JournalPhysical Chemistry Chemical Physics
Volume19
Issue number29
Early online date13 Jul 2017
DOIs
Publication statusE-pub ahead of print - 13 Jul 2017

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