Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1

Nicolas Stifani, Adriana R O Freitas, Anna Liakhovitskaia, Alexander Medvinsky, Artur Kania, Stefano Stifani

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Individual spinal motor neuron identities are specified in large part by the intrinsic repertoire of transcription factors expressed by undifferentiated progenitors and maturing neurons. It is shown here that the transcription factor AML1/Runx1 (Runx1) is expressed in selected spinal motor neuron subtypes after the onset of differentiation and is both necessary and sufficient to suppress interneuron-specific developmental programs and promote maintenance of motor neuron characteristics. These findings show an important role for Runx1 during the consolidation of selected spinal motor neuron identities. Moreover, they suggest a requirement for a persistent suppression of interneuron genes within maturing motor neurons.
Original languageEnglish
Pages (from-to)6451-6
Number of pages6
JournalProceedings of the National Academy of Sciences (PNAS)
Volume105
Issue number17
DOIs
Publication statusPublished - 2008

Keywords / Materials (for Non-textual outputs)

  • lateral motor column
  • median motor column
  • runt
  • spinal cord spinal accessory column

Fingerprint

Dive into the research topics of 'Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1'. Together they form a unique fingerprint.

Cite this