Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1

Nicolas Stifani; Adriana R O Freitas; Anna Liakhovitskaia; Alexander Medvinsky; Artur Kania; Stefano Stifani

doi:10.1073/pnas.0711299105

Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1

Nicolas Stifani, Adriana R O Freitas, Anna Liakhovitskaia, Alexander Medvinsky, Artur Kania, Stefano Stifani

Research output: Contribution to journal › Article › peer-review

Abstract

Individual spinal motor neuron identities are specified in large part by the intrinsic repertoire of transcription factors expressed by undifferentiated progenitors and maturing neurons. It is shown here that the transcription factor AML1/Runx1 (Runx1) is expressed in selected spinal motor neuron subtypes after the onset of differentiation and is both necessary and sufficient to suppress interneuron-specific developmental programs and promote maintenance of motor neuron characteristics. These findings show an important role for Runx1 during the consolidation of selected spinal motor neuron identities. Moreover, they suggest a requirement for a persistent suppression of interneuron genes within maturing motor neurons.

Original language	English
Pages (from-to)	6451-6
Number of pages	6
Journal	Proceedings of the National Academy of Sciences (PNAS)
Volume	105
Issue number	17
DOIs	https://doi.org/10.1073/pnas.0711299105
Publication status	Published - 2008

Keywords / Materials (for Non-textual outputs)

lateral motor column
median motor column
runt
spinal cord spinal accessory column

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10.1073/pnas.0711299105

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title = "Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1",

abstract = "Individual spinal motor neuron identities are specified in large part by the intrinsic repertoire of transcription factors expressed by undifferentiated progenitors and maturing neurons. It is shown here that the transcription factor AML1/Runx1 (Runx1) is expressed in selected spinal motor neuron subtypes after the onset of differentiation and is both necessary and sufficient to suppress interneuron-specific developmental programs and promote maintenance of motor neuron characteristics. These findings show an important role for Runx1 during the consolidation of selected spinal motor neuron identities. Moreover, they suggest a requirement for a persistent suppression of interneuron genes within maturing motor neurons.",

keywords = "lateral motor column, median motor column, runt, spinal cord spinal accessory column",

author = "Nicolas Stifani and Freitas, \{Adriana R O\} and Anna Liakhovitskaia and Alexander Medvinsky and Artur Kania and Stefano Stifani",

year = "2008",

doi = "10.1073/pnas.0711299105",

language = "English",

volume = "105",

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T1 - Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1

AU - Stifani, Nicolas

AU - Freitas, Adriana R O

AU - Liakhovitskaia, Anna

AU - Medvinsky, Alexander

AU - Kania, Artur

AU - Stifani, Stefano

PY - 2008

Y1 - 2008

N2 - Individual spinal motor neuron identities are specified in large part by the intrinsic repertoire of transcription factors expressed by undifferentiated progenitors and maturing neurons. It is shown here that the transcription factor AML1/Runx1 (Runx1) is expressed in selected spinal motor neuron subtypes after the onset of differentiation and is both necessary and sufficient to suppress interneuron-specific developmental programs and promote maintenance of motor neuron characteristics. These findings show an important role for Runx1 during the consolidation of selected spinal motor neuron identities. Moreover, they suggest a requirement for a persistent suppression of interneuron genes within maturing motor neurons.

AB - Individual spinal motor neuron identities are specified in large part by the intrinsic repertoire of transcription factors expressed by undifferentiated progenitors and maturing neurons. It is shown here that the transcription factor AML1/Runx1 (Runx1) is expressed in selected spinal motor neuron subtypes after the onset of differentiation and is both necessary and sufficient to suppress interneuron-specific developmental programs and promote maintenance of motor neuron characteristics. These findings show an important role for Runx1 during the consolidation of selected spinal motor neuron identities. Moreover, they suggest a requirement for a persistent suppression of interneuron genes within maturing motor neurons.

KW - lateral motor column

KW - median motor column

KW - runt

KW - spinal cord spinal accessory column

U2 - 10.1073/pnas.0711299105

DO - 10.1073/pnas.0711299105

M3 - Article

C2 - 18427115

SN - 0027-8424

VL - 105

SP - 6451

EP - 6456

JO - Proceedings of the National Academy of Sciences (PNAS)

JF - Proceedings of the National Academy of Sciences (PNAS)

IS - 17

ER -

Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1

Abstract

Keywords / Materials (for Non-textual outputs)

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