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Plants tailor immune responses to defend against pathogens with different lifestyles. In this process antagonism between the immune hormones salicylic acid (SA) and jasmonic acid (JA)optimizes transcriptional signatures specifically to the attacker encountered. Antagonism is controlled by the transcription cofactor NPR1.The indispensable role of NPR1 in activating SA-responsive genes is well understood, but how it functions as are press or of JA-responsive genes remains unclear. Here we demonstrate that SA-induced NPR1 is recruited to JA-responsive promoter regions that are co-occupied by a JA-induced transcription complex consisting ofMYC2activatorandMED25Mediator subunit. In presence of SA, NPR1physically associatedwithJA-inducedMYC2 and inhibited transcriptional activation by disrupting its interaction with MED25.Importantly,NPR1-mediated inhibition of MYC2 was a major immune mechanism for suppressing pathogen virulence. Thus, NPR1 orchestrates the immune transcriptome not only by activating SA-responsive genes but also by acting as a corepressor of JA-responsive MYC2.
|Number of pages||34|
|Publication status||Published - 14 Dec 2021|
- plant immunity
- salicylic acid
- jasmonic acid
- pseudomonas syringae
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- 5 Finished
Cellular Functions of Proteasome-Associated Ubiquitin Ligase Activity
1/12/19 → 1/04/23
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IMMUNE-EXPRESS: Proteasome-Mediated Gene Expression in Plant Immunity
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