Suppression of MYC transcription activators by the immune cofactor NPR1 fine tunes plant immune responses

Mika Nomoto, Michael Skelly, Tomotaka Itaya, Tsuyoshi Mori, Takamasa Suzuki, Tomonao Matsushita, Mutsutomo Tokizawa, Keiko Kuwata, Hitoshi Mori, Yoshiharu Y Yamamoto, Tetsuya Higashiyama, Hironaka Tsukagoshi, Yasuomi Tada, Steven H Spoel

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Plants tailor immune responses to defend against pathogens with different lifestyles. In this process antagonism between the immune hormones salicylic acid (SA) and jasmonic acid (JA)optimizes transcriptional signatures specifically to the attacker encountered. Antagonism is controlled by the transcription cofactor NPR1.The indispensable role of NPR1 in activating SA-responsive genes is well understood, but how it functions as are press or of JA-responsive genes remains unclear. Here we demonstrate that SA-induced NPR1 is recruited to JA-responsive promoter regions that are co-occupied by a JA-induced transcription complex consisting ofMYC2activatorandMED25Mediator subunit. In presence of SA, NPR1physically associatedwithJA-inducedMYC2 and inhibited transcriptional activation by disrupting its interaction with MED25.Importantly,NPR1-mediated inhibition of MYC2 was a major immune mechanism for suppressing pathogen virulence. Thus, NPR1 orchestrates the immune transcriptome not only by activating SA-responsive genes but also by acting as a corepressor of JA-responsive MYC2.
Original languageEnglish
Article number110125
Number of pages34
JournalCell Reports
Volume37
Issue number11
DOIs
Publication statusPublished - 14 Dec 2021

Keywords / Materials (for Non-textual outputs)

  • plant immunity
  • salicylic acid
  • jasmonic acid
  • coronatine
  • biotroph
  • necrotroph
  • pseudomonas syringae
  • NPR1
  • MYC2
  • MED25

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