Surface engineering of synthetic polymer materials for tissue engineering and regenerative medicine applications

Hassan Rashidi*, Jing Yang, Kevin M. Shakesheff

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

When using polymer materials as scaffolds for tissue engineering or regenerative medicine applications the initial, and often lasting, interaction between cells and the material are via surfaces. Surface engineering is an important strategy in materials fabrication to control and tailor cell interactions whilst preserving desirable bulk materials properties. Surface engineering methods have been described that can strongly influence cell adhesion, migration, proliferation, differentiation and functionality. This review aims to categorise the current strategies for modifying surface chemistry and/or topography in terms of the resultant change in cell behaviour.

Original languageEnglish
Pages (from-to)1318-1331
Number of pages14
JournalBiomaterials science
Volume2
Issue number10
DOIs
Publication statusPublished - 2014

Keywords

  • MESENCHYMAL STEM-CELLS
  • POLYSTYRENE-BLOCK-POLY(TERT-BUTYL ACRYLATE) FILMS
  • NEURAL PROGENITOR CELLS
  • OSTEOBLAST-LIKE CELLS
  • IN-VITRO
  • SUBSTRATE NANOTOPOGRAPHY
  • ELECTROSPUN NANOFIBERS
  • EXTRACELLULAR-MATRIX
  • BIOLOGICAL ANALYSIS
  • POLY(LACTIC ACID)

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