Surface-enhanced Raman scattering in cancer detection and imaging

Marc Vendrell, Kaustabh Kumar Maiti, Kevin Dhaliwal, Young-Tae Chang

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

Technologies that use surface-enhanced Raman scattering (SERS) have experienced significant growth in biomedical research during the past 4 years. In this review we summarize the progress in SERS for cancer diagnostics, including multiplexed detection and identification of new biomarkers, single-nucleotide polymorphisms, and circulating tumor cells. SERS is also used as a non-invasive tool for cancer imaging with immunoSERS microscopy, histological analysis of biopsies, and in vivo detection of tumors. We discuss the future of SERS probes compatible with multiple imaging modalities and their potential for clinical translation (e.g., endoscope-based and intraoperative imaging as tools for surgical guidance). Moreover, we highlight the potential of SERS agents for targeted drug delivery and photothermal therapy.
Original languageEnglish
Pages (from-to)249-257
Number of pages9
JournalTrends in biotechnology
Issue number4
Publication statusPublished - Apr 2013

Keywords / Materials (for Non-textual outputs)

  • diagnostics
  • nanoparticles
  • nanotechnology
  • translational research
  • molecular imaging
  • oncology


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