Survey of caprine PRNP and SPRN allele frequencies in the European Union and their relevance for potential TSE control by selective breeding strategies in goats.

Wilfred Goldmann, C Acin, PL Acutis, U Agrimi, O Andreoletti, F Barillet, C Panagiotidis, S Peletto, T Sklaviadis, G Vaccari, J Langeveld, A Bossers

Research output: Contribution to journalMeeting abstract

Abstract


The prion (PRNP) and shadoo (SPRN) genes in small ruminants are associated with prion disease susceptibility and incubation period length variation. Allelic variants related to disease resistance have been successfully selected in sheep and it appears that we are now at the verge of being able to select similarly in goats. It is therefore of great importance to know the base-line allele and genotype frequencies for PRNP in European Union member states (EU-MS) with endemic scrapie (see also www.goatTSE.eu).
We have analysed approx. 17,000 chromosomes collected from more than 100 herds from seven EU-MS representing all main and some rare breeds. The PRNP open reading frame was sequenced in full for a large proportion contributing to the over 40 protein variants now known to exist in goats. Four PRNP polymorphisms were significantly associated with scrapie resistance when all 680 scrapie cases were compared to healthy controls. Even with this number of animals analysed, many polymorphisms are still quite rare and their role in scrapie susceptibility remains unresolved. We will discuss the PRNP frequency analyses and potential for future breeding programs. Furthermore we will present data supporting the association with scrapie susceptibility of a goat-specific polymorphism in SPRN.
The extent of this genetic study in goats represents a considerable advance reminiscent of the sheep scrapie programs started a decade ago and we predict that it will equally contribute to the reduction and eventual eradication of scrapie from goat herds and populations.


Acknowledgement
The GoatBSE project was supported by EU-project FOOD-CT-2006-36353 and DEFRA, UK to W.G. Continued support is given through EMIDA-ERANET project Goat-TSE-FREE.

Original languageEnglish
Pages (from-to)26
JournalPrion
Volume7
Issue numberSuppt.
Publication statusPublished - May 2013
EventPrion 2013 congress - Banff, Canada, Canada
Duration: 26 May 201330 May 2013

Fingerprint

Dive into the research topics of 'Survey of caprine PRNP and SPRN allele frequencies in the European Union and their relevance for potential TSE control by selective breeding strategies in goats.'. Together they form a unique fingerprint.

Cite this