Projects per year
The prion (PRNP) and shadoo (SPRN) genes in small ruminants are associated with prion disease susceptibility and incubation period length variation. Allelic variants related to disease resistance have been successfully selected in sheep and it appears that we are now at the verge of being able to select similarly in goats. It is therefore of great importance to know the base-line allele and genotype frequencies for PRNP in European Union member states (EU-MS) with endemic scrapie (see also www.goatTSE.eu).
We have analysed approx. 17,000 chromosomes collected from more than 100 herds from seven EU-MS representing all main and some rare breeds. The PRNP open reading frame was sequenced in full for a large proportion contributing to the over 40 protein variants now known to exist in goats. Four PRNP polymorphisms were significantly associated with scrapie resistance when all 680 scrapie cases were compared to healthy controls. Even with this number of animals analysed, many polymorphisms are still quite rare and their role in scrapie susceptibility remains unresolved. We will discuss the PRNP frequency analyses and potential for future breeding programs. Furthermore we will present data supporting the association with scrapie susceptibility of a goat-specific polymorphism in SPRN.
The extent of this genetic study in goats represents a considerable advance reminiscent of the sheep scrapie programs started a decade ago and we predict that it will equally contribute to the reduction and eventual eradication of scrapie from goat herds and populations.
The GoatBSE project was supported by EU-project FOOD-CT-2006-36353 and DEFRA, UK to W.G. Continued support is given through EMIDA-ERANET project Goat-TSE-FREE.
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- 2 Finished
Goat BSE II:: Proposal for improvement of goat TSE discriminate diagnosis and susceptibility based assessment of BSE infectivity in goat-milk and meat
Goldmann, W., Foster, J. & Ryan, K.
1/04/11 → 30/11/12
Goat BSE I: Proposal for improvement of goat TSE discriminative diagnosis and susceptability based assessment of BSE in goat milk and meat - goat BSE
1/05/08 → 30/11/10