Survival of Plasmodium falciparum infected Red Blood Cell Aggregates in Elongational Shear Flow

Anna Jötten, Anabelle Schepp, Adam Machon, Kirsten Moll, Mats Wahlgren, Timm Krüger, Christoph Westerhausen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Rosetting, the formation of red blood cell aggregates, is a life-threatening condition in malaria tropica and not yet fully understood. We study rosette stability using a set of microfluidic stenotic channels, with varied narrowing angle and erythrocytes of blood groups O and A. We find reduced ability of a rosette to pass a stenosis without disruption, the longer the tapered part of the constriction and the narrower the stenosis is. In general, this ability increases with rosette size and is 5-15% higher in blood group A. The experimental results are substantiated by equivalent experiments using lectin-induced red blood cell aggregates and a simulation of the underlying protein binding kinetics.

Original languageEnglish
Pages (from-to)787-797
Number of pages17
JournalLab on a Chip
Volume24
Issue number4
Early online date11 Jan 2024
DOIs
Publication statusE-pub ahead of print - 11 Jan 2024

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