@article{e586be2874864d7b8e700854a59f4c19,
title = "Survival of Plasmodium falciparum infected Red Blood Cell Aggregates in Elongational Shear Flow",
abstract = "Rosetting, the formation of red blood cell aggregates, is a life-threatening condition in malaria tropica and not yet fully understood. We study rosette stability using a set of microfluidic stenotic channels, with varied narrowing angle and erythrocytes of blood groups O and A. We find reduced ability of a rosette to pass a stenosis without disruption, the longer the tapered part of the constriction and the narrower the stenosis is. In general, this ability increases with rosette size and is 5-15\% higher in blood group A. The experimental results are substantiated by equivalent experiments using lectin-induced red blood cell aggregates and a simulation of the underlying protein binding kinetics.",
author = "Anna J{\"o}tten and Anabelle Schepp and Adam Machon and Kirsten Moll and Mats Wahlgren and Timm Kr{\"u}ger and Christoph Westerhausen",
note = "Funding Information: A. M. J. and C. W. would like to acknowledge funding by Nanosystems Initiative Munich (NIM), the Center for NanoScience (CeNS), the “Studienstiftung des deutschen Volkes”, and the “Programm f{\"u}r Chancengleichheit” of the University of Augsburg for financial support, allowing for, among others, several research stays at the Karolinska Institute. C. W. would like to acknowledge funding by the DFG (INST 94/135-1 FUGG, 508235635). Moreover, we thank Dr. Gerhard Schmid for fruitful discussions. Publisher Copyright: {\textcopyright} 2024 The Royal Society of Chemistry.",
year = "2024",
month = jan,
day = "11",
doi = "10.1039/D3LC00552F",
language = "English",
volume = "24",
pages = "787--797",
journal = "Lab on a Chip",
issn = "1473-0197",
publisher = "Royal Society of Chemistry",
number = "4",
}