Symmetries and asymmetries associated with non-random segregation of sister DNA strands in Escherichia coli

Manuel A. Lopez-vernaza, David R.f. Leach

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The successful inheritance of genetic information across generations is a complex process requiring replication of the genome and its faithful segregation into two daughter cells. At each replication cycle there is a risk that new DNA strands incorporate genetic changes caused by miscopying of parental information. By contrast the parental strands retain the original information. This raises the intriguing possibility that specific cell lineages might inherit “immortal” parental DNA strands via non-random segregation. If so, this requires an understanding of the mechanisms of non-random segregation. Here, we review several aspects of asymmetry in the very symmetrical cell, Escherichia coli, in the interest of exploring the potential basis for non-random segregation of leading- and lagging-strand replicated chromosome arms. These considerations lead us to propose a model for DNA replication that integrates chromosome segregation and genomic localisation with non-random strand segregation.
Original languageEnglish
Pages (from-to)610-617
JournalSeminars in Cell and Developmental Biology
Volume24
Issue number8-9
DOIs
Publication statusPublished - 1 Aug 2013

Keywords / Materials (for Non-textual outputs)

  • DNA replication; Sister chromosome segregation; Chromosome dynamics; Immortal strand hypothesis; Escherichia coli

Fingerprint

Dive into the research topics of 'Symmetries and asymmetries associated with non-random segregation of sister DNA strands in Escherichia coli'. Together they form a unique fingerprint.

Cite this