Synapse pathology in Alzheimer's disease

Jessica Griffiths, Seth G N Grant*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Synapse loss and damage are central features of Alzheimer's disease (AD) and contribute to the onset and progression of its behavioural and physiological features. Here we review the literature describing synapse pathology in AD, from what we have learned from microscopy in terms of its impacts on synapse architecture, to the mechanistic role of Aβ, tau and glial cells, mitochondrial dysfunction, and the link with AD risk genes. We consider the emerging view that synapse pathology may operate at a further level, that of synapse diversity, and discuss the prospects for leveraging new synaptome mapping methods to comprehensively understand the molecular properties of vulnerable and resilient synapses. Uncovering AD impacts on brain synapse diversity should inform therapeutic approaches targeted at preserving or replenishing lost and damaged synapses and aid the interpretation of clinical imaging approaches that aim to measure synapse damage.

Original languageEnglish
JournalSeminars in Cell and Developmental Biology
Early online date9 Jun 2022
Publication statusE-pub ahead of print - 9 Jun 2022

Keywords / Materials (for Non-textual outputs)

  • synapse
  • synaptome
  • Alzheimer’s disease
  • microscopy
  • tau


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