Synaptic activity-responsive element (SARE): A unique genomic structure with an unusual sensitivity to neuronal activity

Masatoshi Inoue, Nan Yagishita-Kyo, Mio Nonaka, Takashi Kawashima, Hiroyuki Okuno, Haruhiko Bito

Research output: Contribution to journalArticlepeer-review

Abstract

Formation of a new memory requires plasticity at the synaptic level. However, it has also been shown that the consolidation and the maintenance of such a new memory involve processes that necessitate active mRNA at the nucleus of the cell. How can robust changes in synaptic efficacy specifically drive new transcription and translation of new gene transcripts, and thus transform an otherwise transient plasticity into a long-lasting and stable one? In this article, we highlight the conceptual advance that was gained by the discovery of a potent Synaptic Activity-Responsive Element (SARE) found ∼7 kb upstream of the transcription initiation site of the neuronal immediate early gene Arc. The unique genomic structure of SARE, which contained adjacent and cooperative binding sites for three major activity-dependent transcription factors within a 100-bp locus, was associated with an unusual responsiveness to neuronal stimuli. Taken together, these findings shed light on a new class of transcriptional sensor with enhanced sensitivity to synaptic activity.
Original languageEnglish
Pages (from-to)443-6
Number of pages4
JournalCommunicative and Integrative Biology
Volume3
Issue number5
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Dive into the research topics of 'Synaptic activity-responsive element (SARE): A unique genomic structure with an unusual sensitivity to neuronal activity'. Together they form a unique fingerprint.

Cite this