@article{fd5293ab4c35452e8a3e7d7dbc5fa29f,
title = "Synaptic oligomeric tau in Alzheimer{\textquoteright}s disease – a potential culprit in the spread of tau pathology through the brain",
author = "{Colom Cadena}, Marti and Caitlin Davies and Sonia Sirisi and Ji-Eun Lee and Simzer, {Elizabeth M.} and Makis Tzioras and Marta Querol-Vilaseca and Erika Sanchez-Aced and Chang, {Ya Yin} and Kristjan Holt and McGeachan, {Robert I.} and Jamie Rose and Jane Tulloch and Lewis Wilkins and Colin Smith and Teodora Andrian and Olivia Belbin and Silvia Pujals and Horrocks, {Mathew H} and Alberto Lle{\'o} and Spires-Jones, {Tara L.}",
note = "Funding Information: We gratefully acknowledge the contributions of our brain tissue donors and their families, the Edinburgh Brain and Tissue Bank and Alzheimer's Scotland Dementia Research Centre for coordinating brain tissue donations, Edinburgh Neuroscience for facilitating collaborations, and Prof. Rakez Kayed for generously providing T22 antibody. This work was supported by the Medical Research Council Centres of Excellence in Neurodegeneration (CoEN5025), Centro de Investigaci{\'o}n Biom{\'e}dica en Red en Enfermedades Neurodegenerativas (CIBERNED), the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement no. 681181), and the UK Dementia Research Institute, which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society, and Alzheimer's Research UK. The confocal microscope was generously funded by Alzheimer's Research UK and a Wellcome Trust Institutional Strategic Support Fund at the University of Edinburgh. J.L. was funded by UCB Biopharma, as was the Oxford Nanoimager. M.H. and J.L. acknowledge funding from Dr. Jim Love. Conceptualization, M.C.-C. C.D. M.H.H. A.L. and T.L.S.-J.; methodology, M.C.-C. M.H.H. and T.L.S.-J.; software, M.C.-C. K.H. Y.Y.C. R.I.M. L.W. and T.L.S.-J.; investigation, M.C.-C. C.D. S.S. J.-E.L. E.M.S. M.T. M.Q.-V. E.S.-A. Y.Y.C. R.I.M. J.R. J.T. T.A. O.B. and S.P.; resources, C.S.; writing – first draft, M.C.-C. C.D. M.H.H. A.L. and T.L.S.-J.; writing – editing paper, all authors; funding acquisition, A.L. and T.L.S.-J. T.S.-J. is on the Scientific Advisory Board of Cognition Therapeutics and has received honoraria for talks for industry collaborators. They did not have any involvement in or influence over the current paper. T.S.-J. is also a member of the Neuron Editorial Advisory Board. We worked to ensure gender balance in the recruitment of human subjects. We worked to ensure sex balance in the selection of non-human subjects. One or more of the authors of this paper self-identifies as an underrepresented ethnic minority in their field of research or within their geographical location. One or more of the authors of this paper self-identifies as a gender minority in their field of research. One or more of the authors of this paper self-identifies as a member of the LGBTQIA+ community. We avoided “helicopter science” practices by including the participating local contributors from the region where we conducted the research as authors on the paper. Funding Information: We gratefully acknowledge the contributions of our brain tissue donors and their families, the Edinburgh Brain and Tissue Bank and Alzheimer{\textquoteright}s Scotland Dementia Research Centre for coordinating brain tissue donations, Edinburgh Neuroscience for facilitating collaborations, and Prof. Rakez Kayed for generously providing T22 antibody. This work was supported by the Medical Research Council Centres of Excellence in Neurodegeneration ( CoEN5025 ), Centro de Investigaci{\'o}n Biom{\'e}dica en Red en Enfermedades Neurodegenerativas (CIBERNED), the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement no. 681181 ), and the UK Dementia Research Institute , which receives its funding from DRI Ltd, funded by the UK Medical Research Council , Alzheimer's Society , and Alzheimer{\textquoteright}s Research UK . The confocal microscope was generously funded by Alzheimer{\textquoteright}s Research UK and a Wellcome Trust Institutional Strategic Support Fund at the University of Edinburgh . J.L. was funded by UCB Biopharma , as was the Oxford Nanoimager. M.H. and J.L. acknowledge funding from Dr. Jim Love. Publisher Copyright: {\textcopyright} 2023 The Author(s)",
year = "2023",
month = may,
day = "15",
doi = "10.1016/j.neuron.2023.04.020",
language = "English",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
}