Synaptic tagging and capture in the living rat

K. L. Shires, B. M. Da Silva, J. P. Hawthorne, Richard G M Morris, S. J. Martin

Research output: Contribution to journalArticlepeer-review

Abstract

In isolated hippocampal slices, decaying long-term potentiation can be stabilized and converted to late long-term potentiation lasting many hours, by prior or subsequent strong high-frequency tetanization of an independent input to a common population of neurons-a phenomenon known as 'synaptic tagging and capture'. Here we show that the same phenomenon occurs in the intact rat. Late long-term potentiation can be induced in CA1 during the inhibition of protein synthesis if an independent input is strongly tetanized beforehand. Conversely, declining early long-term potentiation induced by weak tetanization can be converted into lasting late long-term potentiation by subsequent strong tetanization of a separate input. These findings indicate that synaptic tagging and capture is not limited to in vitro preparations; the past and future activity of neurons has a critical role in determining the persistence of synaptic changes in the living animal, thus providing a bridge between cellular studies of protein synthesis-dependent synaptic potentiation and behavioural studies of memory persistence.

Original languageEnglish
Article number1246
Number of pages11
JournalNature Communications
Volume3
DOIs
Publication statusPublished - Dec 2012

Keywords

  • LONG-TERM POTENTIATION
  • MEMORY FORMATION
  • HIPPOCAMPAL CA1
  • LOCAL PROTEIN-SYNTHESIS
  • LTP
  • LATE-PHASE
  • SYNTHESIS INHIBITOR ANISOMYCIN
  • SPATIAL MEMORY
  • FUNCTIONAL PLASTICITY
  • IN-VIVO

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