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Abstract / Description of output
Central nerve terminals contain a small number of synaptic vesicles (SVs) that must sustain the fidelity of neurotransmission across a wide range of stimulation intensities. For this to be achieved, nerve terminals integrate a number of complementary endocytosis modes whose activation spans the breadth of these neuronal stimulation patterns. Two such modes are ultrafast endocytosis and activity-dependent bulk endocytosis, which are triggered by stimuli at either end of the physiological range. Both endocytosis modes generate endosomes directly from the nerve terminal plasma membrane, before the subsequent production of SVs from these structures. This review will discuss the current knowledge relating to the molecular mechanisms involved in the generation of SVs from nerve terminal endosomes, how this relates to other mechanisms of SV production and the functional role of such SVs.
Keywords / Materials (for Non-textual outputs)
- DEPENDENT BULK ENDOCYTOSIS
- CLATHRIN-MEDIATED ENDOCYTOSIS
- MEMBRANE RETRIEVAL
- HIPPOCAMPAL SYNAPSES
- NEUROTRANSMITTER RELEASE
- PROTEIN COMPLEXES
- EHD ATPASE
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- 1 Finished
1/01/12 → 31/12/15