Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo

Sigrid Mensch, Marion Baraban, Rafael Almeida, Tim Czopka, Jessica Ausborn, Abdeljabbar El Manira, David A Lyons

Research output: Contribution to journalArticlepeer-review

Abstract

The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle release impaired CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also found that stimulating neuronal activity increased myelin sheath formation by individual oligodendrocytes. These data indicate that neuronal activity regulates the myelinating capacity of single oligodendrocytes.

Original languageEnglish
Pages (from-to)628-30
Number of pages3
JournalNature Neuroscience
Volume18
Issue number5
Early online date6 Apr 2015
DOIs
Publication statusPublished - 31 May 2015

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