Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo

Sigrid Mensch; Marion Baraban; Rafael Almeida; Tim Czopka; Jessica Ausborn; Abdeljabbar El Manira; David A Lyons

doi:10.1038/nn.3991

Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo

Sigrid Mensch, Marion Baraban, Rafael Almeida, Tim Czopka, Jessica Ausborn, Abdeljabbar El Manira, David A Lyons

Research output: Contribution to journal › Article › peer-review

Abstract

The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle release impaired CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also found that stimulating neuronal activity increased myelin sheath formation by individual oligodendrocytes. These data indicate that neuronal activity regulates the myelinating capacity of single oligodendrocytes.

Original language	English
Pages (from-to)	628-30
Number of pages	3
Journal	Nature Neuroscience
Volume	18
Issue number	5
Early online date	6 Apr 2015
DOIs	https://doi.org/10.1038/nn.3991
Publication status	Published - 31 May 2015

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427868/

David Lyons
- Deanery of Biomedical Sciences - Personal Chair of Neurobiology
- Centre for Discovery Brain Sciences
- Euan MacDonald Centre for Motor Neuron Disease Research
- Edinburgh Neuroscience
Person: Academic: Research Active

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abstract = "The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle release impaired CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also found that stimulating neuronal activity increased myelin sheath formation by individual oligodendrocytes. These data indicate that neuronal activity regulates the myelinating capacity of single oligodendrocytes.",

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AU - Baraban, Marion

AU - Almeida, Rafael

AU - Czopka, Tim

AU - Ausborn, Jessica

AU - El Manira, Abdeljabbar

AU - Lyons, David A

PY - 2015/5/31

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AB - The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle release impaired CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also found that stimulating neuronal activity increased myelin sheath formation by individual oligodendrocytes. These data indicate that neuronal activity regulates the myelinating capacity of single oligodendrocytes.

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Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo

Abstract

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