Syntheses and structures of M(L)(X)BPh4 complexes {M=Co(II), Zn(II); L=cis-1,3,5-tris[3-(2-furyl)prop-2-enylideneamino]cyclohexane, X=0Ac, N03}: structural models of the active site of carbonic anhydrase

L Cronin, S P Foxon, P J Lusby, P H Walton

Research output: Contribution to journalArticlepeer-review

Abstract

The metal coordination geometries in the structures of the zinc(II) and cobalt(II) complexes of the ligand cis-1,3,5-tris[3-(2-furyl)prop-2-enylideneamino]cyclohexane (fr-protach) and with the anions nitrate and acetate are structural models for the active site of carbonic anhydrase. The acetate structures show a striking structural correlation with the metal coordination environments in the known bicarbonate forms of the enzyme. Such structures provide a basis for understanding the marked effect of different metal substitution on the catalytic rate of the enzyme.

Original languageEnglish
Pages (from-to)367-377
Number of pages11
JournalJBIC Journal of Biological Inorganic Chemistry
Volume6
Issue number4
Publication statusPublished - Apr 2001

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