Synthesis and cellular compatibility of multi-block biodegradable poly(ε-caprolactone)-based polyurethanes

F. Khan, M. Bradley, S. Valere, S. Fuhrmann, V. Arrighi

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

A library of block copolymers was synthesized by varying the molecular weight of the poly(ε-caprolactone) (PCL)-diol soft segment (M = 850, 3050, 3700 or 7000), which was reacted with methylene diphenyl diisocyanate (MDI), 1,4-phenylene diisocyanate (PDI), 1,1′-methylenebis(4- isocyanatocyclohexane) (HMDI), or 2,4-toluene diisocyanate (TDI) with 1,4-butanediol (BD) or ethylene glycol (EG) added as chain extenders. Thermal and X-ray measurements indicated that the crystalline structure of the copolymers was largely dependent on the chain length of the PCL-diol, with no crystallization taking place with the smallest diol (M = 850) using MDI, TDI or HMDI. However, the copolymers produced from a PCL-diol (M = 850) and PDI and chain extenders (BD or EG) showed resolved crystalline peaks while no peaks appeared with other diisocyanates. Hydrolytic degradation studies demonstrated a faster degradation rate in the case of more amorphous copolymers than semi-crystalline copolymers. The cellular compatibility of the copolymers was evaluated by fabricating the entire library of polymers in a microarray format and in vitro cell culture, demonstrating that all the 57 copolymers supported cellular attachment and growth.
Original languageEnglish
Pages (from-to)2590-2600
Number of pages11
JournalJournal of Materials Chemistry B: Materials for biology and medicine
Issue number20
Publication statusPublished - 28 May 2013


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