Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

Marc Vendrell, Animesh Samanta, Seong-Wook Yun, Young-Tae Chang

Research output: Contribution to journalArticlepeer-review

Abstract

We report the synthesis and characterization of a novel NIR fluorescent deoxyglucose analogue, CyNE 2-DG. Experiments in different cell lines showed a preferential uptake of CyNE 2-DG in cancer cells and its effective competition with unlabeled D-glucose. Cell imaging experiments demonstrated the superior cell-permeability of CyNE 2-DG over the NIR standard IRDye 800CW 2-DG, and validated its application for cancer cell imaging in the NIR region.

Original languageEnglish
Pages (from-to)4760-4762
Number of pages3
JournalOrganic & Biomolecular chemistry
Volume9
Issue number13
DOIs
Publication statusPublished - 2011

Keywords

  • GLUCOSE-UPTAKE ACTIVITY
  • ESCHERICHIA-COLI
  • 2-NBDG
  • TRANSPORTERS
  • TUMORS
  • PROBE

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