Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

Marc Vendrell; Animesh Samanta; Seong-Wook Yun; Young-Tae Chang

doi:10.1039/c1ob05519d

Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

Marc Vendrell, Animesh Samanta, Seong-Wook Yun, Young-Tae Chang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

We report the synthesis and characterization of a novel NIR fluorescent deoxyglucose analogue, CyNE 2-DG. Experiments in different cell lines showed a preferential uptake of CyNE 2-DG in cancer cells and its effective competition with unlabeled D-glucose. Cell imaging experiments demonstrated the superior cell-permeability of CyNE 2-DG over the NIR standard IRDye 800CW 2-DG, and validated its application for cancer cell imaging in the NIR region.

Original language	English
Pages (from-to)	4760-4762
Number of pages	3
Journal	Organic & Biomolecular chemistry
Volume	9
Issue number	13
DOIs	https://doi.org/10.1039/c1ob05519d
Publication status	Published - 2011

Keywords / Materials (for Non-textual outputs)

GLUCOSE-UPTAKE ACTIVITY
ESCHERICHIA-COLI
2-NBDG
TRANSPORTERS
TUMORS
PROBE

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10.1039/c1ob05519d

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title = "Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging",

abstract = "We report the synthesis and characterization of a novel NIR fluorescent deoxyglucose analogue, CyNE 2-DG. Experiments in different cell lines showed a preferential uptake of CyNE 2-DG in cancer cells and its effective competition with unlabeled D-glucose. Cell imaging experiments demonstrated the superior cell-permeability of CyNE 2-DG over the NIR standard IRDye 800CW 2-DG, and validated its application for cancer cell imaging in the NIR region.",

keywords = "GLUCOSE-UPTAKE ACTIVITY, ESCHERICHIA-COLI, 2-NBDG, TRANSPORTERS, TUMORS, PROBE",

author = "Marc Vendrell and Animesh Samanta and Seong-Wook Yun and Young-Tae Chang",

year = "2011",

doi = "10.1039/c1ob05519d",

language = "English",

volume = "9",

pages = "4760--4762",

journal = "Organic & Biomolecular chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "13",

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T1 - Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

AU - Vendrell, Marc

AU - Samanta, Animesh

AU - Yun, Seong-Wook

AU - Chang, Young-Tae

PY - 2011

Y1 - 2011

N2 - We report the synthesis and characterization of a novel NIR fluorescent deoxyglucose analogue, CyNE 2-DG. Experiments in different cell lines showed a preferential uptake of CyNE 2-DG in cancer cells and its effective competition with unlabeled D-glucose. Cell imaging experiments demonstrated the superior cell-permeability of CyNE 2-DG over the NIR standard IRDye 800CW 2-DG, and validated its application for cancer cell imaging in the NIR region.

AB - We report the synthesis and characterization of a novel NIR fluorescent deoxyglucose analogue, CyNE 2-DG. Experiments in different cell lines showed a preferential uptake of CyNE 2-DG in cancer cells and its effective competition with unlabeled D-glucose. Cell imaging experiments demonstrated the superior cell-permeability of CyNE 2-DG over the NIR standard IRDye 800CW 2-DG, and validated its application for cancer cell imaging in the NIR region.

KW - GLUCOSE-UPTAKE ACTIVITY

KW - ESCHERICHIA-COLI

KW - 2-NBDG

KW - TRANSPORTERS

KW - TUMORS

KW - PROBE

U2 - 10.1039/c1ob05519d

DO - 10.1039/c1ob05519d

M3 - Article

SN - 1477-0520

VL - 9

SP - 4760

EP - 4762

JO - Organic & Biomolecular chemistry

JF - Organic & Biomolecular chemistry

IS - 13

ER -

Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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