Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release

Xuepeng Feng; Guirong Wang; Kevin Neumann; Wei Yao; Lin Ding; Songyan Li; Yang Sheng; Yan Jiang; Mark Bradley; Rong Zhang

doi:10.1016/j.msec.2016.12.009

Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release

Xuepeng Feng, Guirong Wang, Kevin Neumann, Wei Yao, Lin Ding, Songyan Li, Yang Sheng, Yan Jiang, Mark Bradley, Rong Zhang

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Three polyether-ester triblock diols, with various molecular weights, were synthesized from ε-caprolactone and polyethylene glycol and used, with diisocyanates, as soft segments for the preparation of polyurethane acrylate oligomers. The polyurethane acrylates were used to generate cross-linked polyurethane films via UV initiated polymerization with and without cargo incorporation. Degradation experiment indicated that in PBS/H2O2/CoCl2 the films degraded rapidly compared to PBS alone or with lipase. The polyurethane membrane loaded with the antibiotic tetracycline, demonstrated prolonged release over 200h, suggesting that the polymers could be used as an implant coating for controlled drug release.

Original language	English
Pages (from-to)	270-278
Number of pages	9
Journal	Materials Science and Engineering: C
Volume	74
Early online date	7 Dec 2016
DOIs	https://doi.org/10.1016/j.msec.2016.12.009
Publication status	E-pub ahead of print - 7 Dec 2016

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Journal Article

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10.1016/j.msec.2016.12.009

20170608 Bradley Synthesis andCharacterization of Biodegradable Poly-1030Accepted author manuscript, 4.74 MBLicence: Creative Commons: Attribution (CC-BY)

http://www.sciencedirect.com/science/article/pii/S0928493116325115

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title = "Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release",

abstract = "Three polyether-ester triblock diols, with various molecular weights, were synthesized from ε-caprolactone and polyethylene glycol and used, with diisocyanates, as soft segments for the preparation of polyurethane acrylate oligomers. The polyurethane acrylates were used to generate cross-linked polyurethane films via UV initiated polymerization with and without cargo incorporation. Degradation experiment indicated that in PBS/H2O2/CoCl2 the films degraded rapidly compared to PBS alone or with lipase. The polyurethane membrane loaded with the antibiotic tetracycline, demonstrated prolonged release over 200h, suggesting that the polymers could be used as an implant coating for controlled drug release.",

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T1 - Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release

AU - Feng, Xuepeng

AU - Wang, Guirong

AU - Neumann, Kevin

AU - Yao, Wei

AU - Ding, Lin

AU - Li, Songyan

AU - Sheng, Yang

AU - Jiang, Yan

AU - Bradley, Mark

AU - Zhang, Rong

PY - 2016/12/7

Y1 - 2016/12/7

N2 - Three polyether-ester triblock diols, with various molecular weights, were synthesized from ε-caprolactone and polyethylene glycol and used, with diisocyanates, as soft segments for the preparation of polyurethane acrylate oligomers. The polyurethane acrylates were used to generate cross-linked polyurethane films via UV initiated polymerization with and without cargo incorporation. Degradation experiment indicated that in PBS/H2O2/CoCl2 the films degraded rapidly compared to PBS alone or with lipase. The polyurethane membrane loaded with the antibiotic tetracycline, demonstrated prolonged release over 200h, suggesting that the polymers could be used as an implant coating for controlled drug release.

AB - Three polyether-ester triblock diols, with various molecular weights, were synthesized from ε-caprolactone and polyethylene glycol and used, with diisocyanates, as soft segments for the preparation of polyurethane acrylate oligomers. The polyurethane acrylates were used to generate cross-linked polyurethane films via UV initiated polymerization with and without cargo incorporation. Degradation experiment indicated that in PBS/H2O2/CoCl2 the films degraded rapidly compared to PBS alone or with lipase. The polyurethane membrane loaded with the antibiotic tetracycline, demonstrated prolonged release over 200h, suggesting that the polymers could be used as an implant coating for controlled drug release.

KW - Journal Article

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DO - 10.1016/j.msec.2016.12.009

M3 - Article

C2 - 28254295

SN - 0928-4931

VL - 74

SP - 270

EP - 278

JO - Materials Science and Engineering: C

JF - Materials Science and Engineering: C

ER -

Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release

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