Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release

Xuepeng Feng, Guirong Wang, Kevin Neumann, Wei Yao, Lin Ding, Songyan Li, Yang Sheng, Yan Jiang, Mark Bradley, Rong Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Three polyether-ester triblock diols, with various molecular weights, were synthesized from ε-caprolactone and polyethylene glycol and used, with diisocyanates, as soft segments for the preparation of polyurethane acrylate oligomers. The polyurethane acrylates were used to generate cross-linked polyurethane films via UV initiated polymerization with and without cargo incorporation. Degradation experiment indicated that in PBS/H2O2/CoCl2 the films degraded rapidly compared to PBS alone or with lipase. The polyurethane membrane loaded with the antibiotic tetracycline, demonstrated prolonged release over 200h, suggesting that the polymers could be used as an implant coating for controlled drug release.

Original languageEnglish
Pages (from-to)270-278
Number of pages9
JournalMaterials Science and Engineering: C
Volume74
Early online date7 Dec 2016
DOIs
Publication statusE-pub ahead of print - 7 Dec 2016

Keywords

  • Journal Article

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