Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds

Thais Gaban Passalacqua, Luiz Antonio Dutra, Letícia De Almeida, Angela Maria Arenas Velásquez, Fabio Aurelio Torres Esteves, Paulo Renato Yamasaki, Mariana Dos Santos Bastos, Luis Octavio Regasini, Paul A.M. Michels, Vanderlan Da Silva Bolzani, Marcia A.S. Graminha*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Chalcones form a class of compounds that belong to the flavonoid family and are widely distributed in plants. Their simple structure and the ease of preparation make chalcones attractive scaffolds for the synthesis of a large number of derivatives enabling the evaluation of the effects of different functional groups on biological activities. In this Letter, we report the successful synthesis of a series of novel prenylated chalcones via Claisen-Schmidt condensation and the evaluation of their effect on the viability of the Trypanosomatidae parasites Leishmania amazonensis, Leishmania infantum and Trypanosoma cruzi.

Original languageEnglish
Article number22762
Pages (from-to)3342-3345
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number16
Early online date30 May 2015
DOIs
Publication statusPublished - 3 Jul 2015

Keywords

  • drug discovery
  • leishmania amazonensis
  • leishmania infantum
  • leishmanicidal activity
  • prenylated chalcone
  • trypanocidal activity
  • trypanosoma cruzi

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