Synthesis and solid state structure of a hydrazone-disulfide macrocycle and its dynamic covalent ring-opening under acidic and basic conditions

Max von Delius, Edzard M. Geertsema, David A. Leigh, Alexandra M. Z. Slawin

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis and characterisation, including solid state structure, of a macrocycle containing both a hydrazone and a disulfide linkage is described. Selective ring-opening of the macrocycle under thermodynamic control could be achieved at either the disulfide or the hydrazone linkage by applying mutually exclusive sets of reaction conditions.

Original languageEnglish
Pages (from-to)4617-4624
Number of pages8
JournalOrganic & Biomolecular chemistry
Volume8
Issue number20
DOIs
Publication statusPublished - 2010

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