Abstract / Description of output
The synthesis and characterization of four new nitroxide-radical-containing next-generation maleimides are presented. Each new label has a single leaving group which is either a phenoxyl or bromide. The linker between the maleimide and the nitroxide-containing framework is either a racemic mixture of a short chain or an achiral longer chain. These molecules have been designed to site-specifically label vicinal cysteines in proteins for magnetic resonance studies. The characterization of the final products includes crystallography and the labeling of sperm whale myoglobin protein.
Original language | English |
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Pages (from-to) | 2357-2361 |
Number of pages | 5 |
Journal | Accounts and Rapid Communications in Chemical Synthesis (SYNLETT) |
Volume | 27 |
Issue number | 16 |
Early online date | 5 Jul 2016 |
DOIs | |
Publication status | Published - 1 Oct 2016 |