Synthesis of Next Generation Maleimide Radical Labels

Bouchra Hajjaj, Anokhi Shah, Sally L. Shirran, Catherine H. Botting, Alexandra M. Z. Slawin, Alison Nicola Hulme, Janet E. Lovett

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis and characterization of four new nitroxide-radical-containing next-generation maleimides are presented. Each new label has a single leaving group which is either a phenoxyl or bromide. The linker between the maleimide and the nitroxide-containing framework is either a racemic mixture of a short chain or an achiral longer chain. These molecules have been designed to site-specifically label vicinal cysteines in proteins for magnetic resonance studies. The characterization of the final products includes crystallography and the labeling of sperm whale myoglobin protein.
Original languageEnglish
Pages (from-to)2357-2361
Number of pages5
Journal Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry
Volume27
Issue number16
Early online date5 Jul 2016
DOIs
Publication statusPublished - 1 Oct 2016

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