Synthesis of the conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids

Francis N. Murigi; Gary S. Nichol; Eugene A. Mash

doi:10.1021/jo902438s

Synthesis of the conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids

Francis N. Murigi, Gary S. Nichol, Eugene A. Mash

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

(Chemical Equation Presented) The conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids, were prepared by chromatographic separation of diastereomeric dipeptide derivatives formed from N-Boc-L-phenylalanine. Absolute configurations were assigned by X-ray crystallographic analysis.

Original language	English
Pages (from-to)	1293-1296
Number of pages	4
Journal	The Journal of Organic Chemistry (JOC)
Volume	75
Issue number	4
DOIs	https://doi.org/10.1021/jo902438s
Publication status	Published - 19 Feb 2010

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title = "Synthesis of the conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids",

abstract = "(Chemical Equation Presented) The conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids, were prepared by chromatographic separation of diastereomeric dipeptide derivatives formed from N-Boc-L-phenylalanine. Absolute configurations were assigned by X-ray crystallographic analysis.",

author = "Murigi, {Francis N.} and Nichol, {Gary S.} and Mash, {Eugene A.}",

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AU - Murigi, Francis N.

AU - Nichol, Gary S.

AU - Mash, Eugene A.

PY - 2010/2/19

Y1 - 2010/2/19

N2 - (Chemical Equation Presented) The conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids, were prepared by chromatographic separation of diastereomeric dipeptide derivatives formed from N-Boc-L-phenylalanine. Absolute configurations were assigned by X-ray crystallographic analysis.

AB - (Chemical Equation Presented) The conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids, were prepared by chromatographic separation of diastereomeric dipeptide derivatives formed from N-Boc-L-phenylalanine. Absolute configurations were assigned by X-ray crystallographic analysis.

U2 - 10.1021/jo902438s

DO - 10.1021/jo902438s

M3 - Article

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AN - SCOPUS:77249126422

SN - 0022-3263

VL - 75

SP - 1293

EP - 1296

JO - The Journal of Organic Chemistry (JOC)

JF - The Journal of Organic Chemistry (JOC)

IS - 4

ER -

Synthesis of the conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids

Abstract

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