Systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops

H Chiapello; I Bourgait; F Sourivong; G Heuclin; A Gendrault-Jacquemard; M-A Petit; M El Karoui

doi:10.1186/1471-2105-6-171

Systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops

H Chiapello, I Bourgait, F Sourivong, G Heuclin, A Gendrault-Jacquemard, M-A Petit, M El Karoui

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Public databases now contain multitude of complete bacterial genomes, including several genomes of the same species. The available data offers new opportunities to address questions about bacterial genome evolution, a task that requires reliable fine comparison data of closely related genomes. Recent analyses have shown, using pairwise whole genome alignments, that it is possible to segment bacterial genomes into a common conserved backbone and strain-specific sequences called loops.

Original language	English
Article number	171
Number of pages	10
Journal	BMC Bioinformatics
Volume	6
DOIs	https://doi.org/10.1186/1471-2105-6-171
Publication status	Published - 2005

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title = "Systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops",

abstract = "Public databases now contain multitude of complete bacterial genomes, including several genomes of the same species. The available data offers new opportunities to address questions about bacterial genome evolution, a task that requires reliable fine comparison data of closely related genomes. Recent analyses have shown, using pairwise whole genome alignments, that it is possible to segment bacterial genomes into a common conserved backbone and strain-specific sequences called loops.",

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AU - Gendrault-Jacquemard, A

AU - Petit, M-A

AU - El Karoui, M

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AB - Public databases now contain multitude of complete bacterial genomes, including several genomes of the same species. The available data offers new opportunities to address questions about bacterial genome evolution, a task that requires reliable fine comparison data of closely related genomes. Recent analyses have shown, using pairwise whole genome alignments, that it is possible to segment bacterial genomes into a common conserved backbone and strain-specific sequences called loops.

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JF - BMC Bioinformatics

SN - 1471-2105

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Systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops

Abstract

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