Systematic Review and Meta-Analysis of Haemostatic and Biliostatic Efficacy of Fibrin Sealants in Elective Liver Surgery

Pandanaboyana Sanjay; David G Watt; Stephen J Wigmore

doi:10.1007/s11605-012-2055-7

Systematic Review and Meta-Analysis of Haemostatic and Biliostatic Efficacy of Fibrin Sealants in Elective Liver Surgery

Pandanaboyana Sanjay, David G Watt, Stephen J Wigmore

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Fibrin sealants are frequently used in liver surgery to achieve intraoperative haemostasis and reduce post-operative haemorrhage and bile leak. This meta-analysis aimed to review the haemostatic and biliostatic capacity of fibrin sealants in elective liver surgery. METHODS: An electronic search was performed on the MEDLINE, Embase and PubMed databases using both subject headings and truncated word searches to identify all published articles that are related to this topic. Pooled risk ratios were calculated for categorical outcomes, and mean differences for secondary continuous outcomes, using the fixed-effects and random-effects models for meta-analysis. RESULTS: Ten randomised controlled trials encompassing 1,225 patients were analysed to achieve a summated outcome. Pooled data analysis showed the use of fibrin sealants resulted in reduced time to haemostasis (mean difference -3.45 min [-3.78, -3.13] (P

Original language	English
Journal	Journal of Gastrointestinal Surgery
Volume	17
Issue number	4
DOIs	https://doi.org/10.1007/s11605-012-2055-7
Publication status	Published - Apr 2013

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10.1007/s11605-012-2055-7

PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY
Iredale, J. (Principal Investigator)
MRC
1/09/12 → 31/08/16
Project: Research

Cite this

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title = "Systematic Review and Meta-Analysis of Haemostatic and Biliostatic Efficacy of Fibrin Sealants in Elective Liver Surgery",

abstract = "BACKGROUND: Fibrin sealants are frequently used in liver surgery to achieve intraoperative haemostasis and reduce post-operative haemorrhage and bile leak. This meta-analysis aimed to review the haemostatic and biliostatic capacity of fibrin sealants in elective liver surgery. METHODS: An electronic search was performed on the MEDLINE, Embase and PubMed databases using both subject headings and truncated word searches to identify all published articles that are related to this topic. Pooled risk ratios were calculated for categorical outcomes, and mean differences for secondary continuous outcomes, using the fixed-effects and random-effects models for meta-analysis. RESULTS: Ten randomised controlled trials encompassing 1,225 patients were analysed to achieve a summated outcome. Pooled data analysis showed the use of fibrin sealants resulted in reduced time to haemostasis (mean difference -3.45 min [-3.78, -3.13] (P ",

author = "Pandanaboyana Sanjay and Watt, {David G} and Wigmore, {Stephen J}",

year = "2013",

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publisher = "Society for Surgery of the Alimentary Tract",

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TY - JOUR

T1 - Systematic Review and Meta-Analysis of Haemostatic and Biliostatic Efficacy of Fibrin Sealants in Elective Liver Surgery

AU - Sanjay, Pandanaboyana

AU - Watt, David G

AU - Wigmore, Stephen J

PY - 2013/4

Y1 - 2013/4

N2 - BACKGROUND: Fibrin sealants are frequently used in liver surgery to achieve intraoperative haemostasis and reduce post-operative haemorrhage and bile leak. This meta-analysis aimed to review the haemostatic and biliostatic capacity of fibrin sealants in elective liver surgery. METHODS: An electronic search was performed on the MEDLINE, Embase and PubMed databases using both subject headings and truncated word searches to identify all published articles that are related to this topic. Pooled risk ratios were calculated for categorical outcomes, and mean differences for secondary continuous outcomes, using the fixed-effects and random-effects models for meta-analysis. RESULTS: Ten randomised controlled trials encompassing 1,225 patients were analysed to achieve a summated outcome. Pooled data analysis showed the use of fibrin sealants resulted in reduced time to haemostasis (mean difference -3.45 min [-3.78, -3.13] (P

AB - BACKGROUND: Fibrin sealants are frequently used in liver surgery to achieve intraoperative haemostasis and reduce post-operative haemorrhage and bile leak. This meta-analysis aimed to review the haemostatic and biliostatic capacity of fibrin sealants in elective liver surgery. METHODS: An electronic search was performed on the MEDLINE, Embase and PubMed databases using both subject headings and truncated word searches to identify all published articles that are related to this topic. Pooled risk ratios were calculated for categorical outcomes, and mean differences for secondary continuous outcomes, using the fixed-effects and random-effects models for meta-analysis. RESULTS: Ten randomised controlled trials encompassing 1,225 patients were analysed to achieve a summated outcome. Pooled data analysis showed the use of fibrin sealants resulted in reduced time to haemostasis (mean difference -3.45 min [-3.78, -3.13] (P

U2 - 10.1007/s11605-012-2055-7

DO - 10.1007/s11605-012-2055-7

M3 - Article

C2 - 23086450

SN - 1873-4626

VL - 17

JO - Journal of Gastrointestinal Surgery

JF - Journal of Gastrointestinal Surgery

IS - 4

ER -

Systematic Review and Meta-Analysis of Haemostatic and Biliostatic Efficacy of Fibrin Sealants in Elective Liver Surgery

Abstract

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PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY

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