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Abstract
BACKGROUND: Fibrin sealants are frequently used in liver surgery to achieve intraoperative haemostasis and reduce post-operative haemorrhage and bile leak. This meta-analysis aimed to review the haemostatic and biliostatic capacity of fibrin sealants in elective liver surgery. METHODS: An electronic search was performed on the MEDLINE, Embase and PubMed databases using both subject headings and truncated word searches to identify all published articles that are related to this topic. Pooled risk ratios were calculated for categorical outcomes, and mean differences for secondary continuous outcomes, using the fixed-effects and random-effects models for meta-analysis. RESULTS: Ten randomised controlled trials encompassing 1,225 patients were analysed to achieve a summated outcome. Pooled data analysis showed the use of fibrin sealants resulted in reduced time to haemostasis (mean difference -3.45 min [-3.78, -3.13] (P
Original language | English |
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Journal | Journal of Gastrointestinal Surgery |
Volume | 17 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2013 |
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Dive into the research topics of 'Systematic Review and Meta-Analysis of Haemostatic and Biliostatic Efficacy of Fibrin Sealants in Elective Liver Surgery'. Together they form a unique fingerprint.Projects
- 1 Finished
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PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY
Iredale, J. (Principal Investigator)
1/09/12 → 31/08/16
Project: Research