Systematic review and meta-analysis of therapeutic hypothermia in animal models of spinal cord injury

Peter E Batchelor, Peta Skeers, Ana Antonic, Taryn E Wills, David W Howells, Malcolm R Macleod, Emily S Sena

Research output: Contribution to journalArticlepeer-review

Abstract

Therapeutic hypothermia is a clinically useful neuroprotective therapy for cardiac arrest and neonatal hypoxic ischemic encephalopathy and may potentially be useful for the treatment of other neurological conditions including traumatic spinal cord injury (SCI). The pre-clinical studies evaluating the effectiveness of hypothermia in acute SCI broadly utilise either systemic hypothermia or cooling regional to the site of injury. The literature has not been uniformly positive with conflicting studies of varying quality, some performed decades previously.
Original languageEnglish
Pages (from-to)e71317
JournalPLoS ONE
Volume8
Issue number8
DOIs
Publication statusPublished - 2013

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