Systematic review and meta-analysis: Prevalence and possible causes of vitamin D deficiency and insufficiency in pediatric cancer patients

R. Revuelta Iniesta*, R. Rush, I. Paciarotti, E. B. Rhatigan, F. H. M. Brougham, J. M. McKenzie, D. C. Wilson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Background and aims: Vitamin D inadequacy is now an internationally recognized health problem and pediatric cancer patients may be at even higher risk than healthy children. We aimed to evaluate primary research to establish the prevalence of vitamin D inadequacy and to explore its possible causes in pediatric cancer patients.

Methods: Electronic databases were searched (no restriction-Aug 2013) with no language restrictions and keywords related to cancer and vitamin D. We included studies of patients aged

Results: We included 19 studies, which were mainly of moderate-quality and heterogeneous in the definitions of vitamin D deficiency and insufficiency. The median (range) prevalence of vitamin D deficiency was 14% (0-61.5%) and insufficiency 23% (0-83%). Finally, a significant effect of younger age with vitamin D inadequacy was shown (effect size: -0.132; 95%CI -0.203, -0.060).

Conclusion: There is a possibility of a high prevalence of vitamin D inadequacy in pediatric cancer patients, especially older children, urging the need for high-quality population-based longitudinal studies using standard definitions. (C) 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Original languageEnglish
Pages (from-to)95-108
Number of pages14
JournalClinical Nutrition
Volume35
Issue number1
Early online date16 Jan 2015
DOIs
Publication statusPublished - Feb 2016

Keywords / Materials (for Non-textual outputs)

  • Vitamin D
  • 25(OH)D status,1,25(OH)D
  • Vitamin D deficiency
  • Prevalence
  • Pediatric cancer
  • BONE-MINERAL DENSITY
  • ACUTE LYMPHOBLASTIC-LEUKEMIA
  • D-BINDING PROTEIN
  • CHILDHOOD-CANCER
  • 25-HYDROXYVITAMIN D
  • D SUPPLEMENTATION
  • CHILDREN
  • SURVIVORS
  • MASS
  • CHEMOTHERAPY

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