Systemic inflammation and stroke: aetiology, pathology and targets for therapy

B. W. McColl, S. M. Allan, N. J. Rothwell

Research output: Contribution to journalArticlepeer-review


There is growing evidence that systemic inflammation is involved in multiple aspects of stroke aetiology and pathology. in the present review, we provide an overview of these roles and, in particular, outline recent evidence that the underlying systemic inflammatory profile can critically alter the response to ischaemic brain injury. We also highlight the need for stroke models to more adequately account for the involvement of underlying systemic inflammation.

Original languageEnglish
Pages (from-to)1163-1165
Number of pages3
JournalBiochemical Society Transactions
Issue number5
Publication statusPublished - Nov 2007
EventLife Science 2007 - Glasgow, United Kingdom
Duration: 12 Jul 200712 Jul 2007

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