Systemic inflammation enhances activated astrocyte heterogeneity and accelerates neurodegeneration

Barry Bradford, David Donaldson, Christianus Wijaya, Kathryn Else, Neil Mabbott

Research output: Contribution to conferencePosterpeer-review


Prion infections in the central nervous system (CNS) can cause extensive neurodegeneration. Systemic inflammation can affect the progression of some neurodegenerative disorders. The gastrointestinal helminth pathogen Trichuris muris was used to stimulate a chronic systemic inflammation, characterised by T helper cell type 1-polarized and high serum Interferon gamma (IFNγ) responses, to determine the impact on prion disease progression and neuropathology.
Original languageEnglish
Publication statusPublished - 11 Mar 2020
EventEdinburgh Neuroscience day 2020 -
Duration: 11 Mar 202011 Mar 2020


ConferenceEdinburgh Neuroscience day 2020
Abbreviated titleNeuroscience Day 2020
Internet address


  • Inflammation
  • astrocytes
  • neurodegeneration
  • Prions
  • Trichuris muris
  • Pathogen


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