Systemic inflammation enhances activated astrocyte heterogeneity and accelerates neurodegeneration

Barry Bradford; David Donaldson; Christianus Wijaya; Kathryn  Else; Neil Mabbott

Systemic inflammation enhances activated astrocyte heterogeneity and accelerates neurodegeneration

Barry Bradford, David Donaldson, Christianus Wijaya, Kathryn Else, Neil Mabbott

Research output: Contribution to conference › Poster › peer-review

Abstract

Prion infections in the central nervous system (CNS) can cause extensive neurodegeneration. Systemic inflammation can affect the progression of some neurodegenerative disorders. The gastrointestinal helminth pathogen Trichuris muris was used to stimulate a chronic systemic inflammation, characterised by T helper cell type 1-polarized and high serum Interferon gamma (IFNγ) responses, to determine the impact on prion disease progression and neuropathology.

Original language	English
Publication status	Published - 11 Mar 2020
Event	Edinburgh Neuroscience day 2020 - Duration: 11 Mar 2020 → 11 Mar 2020 https://www.edinburghneuroscience.ed.ac.uk/events/neuroscience-day-2020

Conference

Conference	Edinburgh Neuroscience day 2020
Abbreviated title	Neuroscience Day 2020
Period	11/03/20 → 11/03/20
Internet address	https://www.edinburghneuroscience.ed.ac.uk/events/neuroscience-day-2020

Keywords

Inflammation
astrocytes
neurodegeneration
Prions
Trichuris muris
Pathogen

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2020 Neuroscience day AstrocytesFinal published version, 29.3 MB

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title = "Systemic inflammation enhances activated astrocyte heterogeneity and accelerates neurodegeneration",

abstract = "Prion infections in the central nervous system (CNS) can cause extensive neurodegeneration. Systemic inflammation can affect the progression of some neurodegenerative disorders. The gastrointestinal helminth pathogen Trichuris muris was used to stimulate a chronic systemic inflammation, characterised by T helper cell type 1-polarized and high serum Interferon gamma (IFNγ) responses, to determine the impact on prion disease progression and neuropathology.",

keywords = "Inflammation, astrocytes, neurodegeneration, Prions, Trichuris muris, Pathogen",

author = "Barry Bradford and David Donaldson and Christianus Wijaya and Kathryn Else and Neil Mabbott",

year = "2020",

month = mar,

day = "11",

language = "English",

note = "Edinburgh Neuroscience day 2020, Neuroscience Day 2020 ; Conference date: 11-03-2020 Through 11-03-2020",

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TY - CONF

T1 - Systemic inflammation enhances activated astrocyte heterogeneity and accelerates neurodegeneration

AU - Bradford, Barry

AU - Donaldson, David

AU - Wijaya, Christianus

AU - Else, Kathryn

AU - Mabbott, Neil

PY - 2020/3/11

Y1 - 2020/3/11

N2 - Prion infections in the central nervous system (CNS) can cause extensive neurodegeneration. Systemic inflammation can affect the progression of some neurodegenerative disorders. The gastrointestinal helminth pathogen Trichuris muris was used to stimulate a chronic systemic inflammation, characterised by T helper cell type 1-polarized and high serum Interferon gamma (IFNγ) responses, to determine the impact on prion disease progression and neuropathology.

AB - Prion infections in the central nervous system (CNS) can cause extensive neurodegeneration. Systemic inflammation can affect the progression of some neurodegenerative disorders. The gastrointestinal helminth pathogen Trichuris muris was used to stimulate a chronic systemic inflammation, characterised by T helper cell type 1-polarized and high serum Interferon gamma (IFNγ) responses, to determine the impact on prion disease progression and neuropathology.

KW - Inflammation

KW - astrocytes

KW - neurodegeneration

KW - Prions

KW - Trichuris muris

KW - Pathogen

M3 - Poster

T2 - Edinburgh Neuroscience day 2020

Y2 - 11 March 2020 through 11 March 2020

ER -

Systemic inflammation enhances activated astrocyte heterogeneity and accelerates neurodegeneration

Abstract

Conference

Keywords

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