Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer

Mark S Duxbury, Evan Matros, Hiromichi Ito, Michael J Zinner, Stanley W Ashley, Edward E Whang

Research output: Contribution to journalArticlepeer-review

Abstract

RNA interference (RNAi), mediated by small interfering RNA (siRNA), silences genes with a high degree of specificity and potentially represents a general approach for molecularly targeted anticancer therapy. The aim of this study was to evaluate the ability of systemically administered siRNA to silence gene expression in vivo and to assess the effect of this approach on tumor growth using a murine pancreatic adenocarcinoma xenograft model.
Original languageEnglish
Pages (from-to)667-74; discussion 675-6
JournalAnnals of Surgery
Volume240
Issue number4
DOIs
Publication statusPublished - 2004

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