Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease

TESRA and ECLIPSE Investigators; Donavan T Cheng; Deog Kyeom Kim; Debra A Cockayne; Anton Belousov; Hans Bitter; Michael H Cho; Annelyse Duvoix; Lisa D Edwards; David A Lomas; Bruce E Miller; Niki Reynaert; Ruth Tal-Singer; Emiel F M Wouters; Alvar Agustí; Leonardo M Fabbri; Alex Rames; Sudha Visvanathan; Stephen I Rennard; Paul Jones; Harsukh Parmar; William MacNee; Gerhard Wolff; Edwin K Silverman; Ruth J Mayer; Sreekumar G Pillai

doi:10.1164/rccm.201302-0247OC

Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease

TESRA and ECLIPSE Investigators, Donavan T Cheng, Deog Kyeom Kim, Debra A Cockayne, Anton Belousov, Hans Bitter, Michael H Cho, Annelyse Duvoix, Lisa D Edwards, David A Lomas, Bruce E Miller, Niki Reynaert, Ruth Tal-Singer, Emiel F M Wouters, Alvar Agustí, Leonardo M Fabbri, Alex Rames, Sudha Visvanathan, Stephen I Rennard, Paul JonesHarsukh Parmar, William MacNee, Gerhard Wolff, Edwin K Silverman, Ruth J Mayer, Sreekumar G Pillai

Research output: Contribution to journal › Article › peer-review

Abstract

Emphysema in chronic obstructive pulmonary disease (COPD) can be characterized by high-resolution chest computed tomography (HRCT); however, the repeated use of HRCT is limited because of concerns regarding radiation exposure and cost.

Original language	English
Pages (from-to)	948-57
Number of pages	10
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	188
Issue number	8
DOIs	https://doi.org/10.1164/rccm.201302-0247OC
Publication status	Published - 15 Oct 2013

Keywords

Aged
Biological Markers
Emphysema
Female
Humans
Lung
Male
Middle Aged
Polymorphism, Single Nucleotide
Pulmonary Disease, Chronic Obstructive
Receptors, Immunologic
Severity of Illness Index
Tomography, Spiral Computed

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10.1164/rccm.201302-0247OC

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PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY
Iredale, J.
MRC
1/09/12 → 31/08/16
Project: Research

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TESRA and ECLIPSE Investigators, Cheng, D. T., Kim, D. K., Cockayne, D. A., Belousov, A., Bitter, H., Cho, M. H., Duvoix, A., Edwards, L. D., Lomas, D. A., Miller, B. E., Reynaert, N., Tal-Singer, R., Wouters, E. F. M., Agustí, A., Fabbri, L. M., Rames, A., Visvanathan, S., Rennard, S. I., ... Pillai, S. G. (2013). Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 188(8), 948-57. https://doi.org/10.1164/rccm.201302-0247OC

TESRA and ECLIPSE Investigators ; Cheng, Donavan T ; Kim, Deog Kyeom ; Cockayne, Debra A ; Belousov, Anton ; Bitter, Hans ; Cho, Michael H ; Duvoix, Annelyse ; Edwards, Lisa D ; Lomas, David A ; Miller, Bruce E ; Reynaert, Niki ; Tal-Singer, Ruth ; Wouters, Emiel F M ; Agustí, Alvar ; Fabbri, Leonardo M ; Rames, Alex ; Visvanathan, Sudha ; Rennard, Stephen I ; Jones, Paul ; Parmar, Harsukh ; MacNee, William ; Wolff, Gerhard ; Silverman, Edwin K ; Mayer, Ruth J ; Pillai, Sreekumar G. / Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. In: American Journal of Respiratory and Critical Care Medicine. 2013 ; Vol. 188, No. 8. pp. 948-57.

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title = "Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease",

abstract = "Emphysema in chronic obstructive pulmonary disease (COPD) can be characterized by high-resolution chest computed tomography (HRCT); however, the repeated use of HRCT is limited because of concerns regarding radiation exposure and cost.",

keywords = "Aged, Biological Markers, Emphysema, Female, Humans, Lung, Male, Middle Aged, Polymorphism, Single Nucleotide, Pulmonary Disease, Chronic Obstructive, Receptors, Immunologic, Severity of Illness Index, Tomography, Spiral Computed",

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doi = "10.1164/rccm.201302-0247OC",

language = "English",

volume = "188",

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journal = "American Journal of Respiratory and Critical Care Medicine",

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TESRA and ECLIPSE Investigators, Cheng, DT, Kim, DK, Cockayne, DA, Belousov, A, Bitter, H, Cho, MH, Duvoix, A, Edwards, LD, Lomas, DA, Miller, BE, Reynaert, N, Tal-Singer, R, Wouters, EFM, Agustí, A, Fabbri, LM, Rames, A, Visvanathan, S, Rennard, SI, Jones, P, Parmar, H, MacNee, W, Wolff, G, Silverman, EK, Mayer, RJ & Pillai, SG 2013, 'Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, vol. 188, no. 8, pp. 948-57. https://doi.org/10.1164/rccm.201302-0247OC

Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. / TESRA and ECLIPSE Investigators; Cheng, Donavan T; Kim, Deog Kyeom; Cockayne, Debra A; Belousov, Anton; Bitter, Hans; Cho, Michael H; Duvoix, Annelyse; Edwards, Lisa D; Lomas, David A; Miller, Bruce E; Reynaert, Niki; Tal-Singer, Ruth; Wouters, Emiel F M; Agustí, Alvar; Fabbri, Leonardo M; Rames, Alex; Visvanathan, Sudha; Rennard, Stephen I; Jones, Paul; Parmar, Harsukh; MacNee, William; Wolff, Gerhard; Silverman, Edwin K; Mayer, Ruth J; Pillai, Sreekumar G.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 188, No. 8, 15.10.2013, p. 948-57.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease

AU - TESRA and ECLIPSE Investigators

AU - Cheng, Donavan T

AU - Kim, Deog Kyeom

AU - Cockayne, Debra A

AU - Belousov, Anton

AU - Bitter, Hans

AU - Cho, Michael H

AU - Duvoix, Annelyse

AU - Edwards, Lisa D

AU - Lomas, David A

AU - Miller, Bruce E

AU - Reynaert, Niki

AU - Tal-Singer, Ruth

AU - Wouters, Emiel F M

AU - Agustí, Alvar

AU - Fabbri, Leonardo M

AU - Rames, Alex

AU - Visvanathan, Sudha

AU - Rennard, Stephen I

AU - Jones, Paul

AU - Parmar, Harsukh

AU - MacNee, William

AU - Wolff, Gerhard

AU - Silverman, Edwin K

AU - Mayer, Ruth J

AU - Pillai, Sreekumar G

PY - 2013/10/15

Y1 - 2013/10/15

N2 - Emphysema in chronic obstructive pulmonary disease (COPD) can be characterized by high-resolution chest computed tomography (HRCT); however, the repeated use of HRCT is limited because of concerns regarding radiation exposure and cost.

AB - Emphysema in chronic obstructive pulmonary disease (COPD) can be characterized by high-resolution chest computed tomography (HRCT); however, the repeated use of HRCT is limited because of concerns regarding radiation exposure and cost.

KW - Aged

KW - Biological Markers

KW - Emphysema

KW - Female

KW - Humans

KW - Lung

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Pulmonary Disease, Chronic Obstructive

KW - Receptors, Immunologic

KW - Severity of Illness Index

KW - Tomography, Spiral Computed

U2 - 10.1164/rccm.201302-0247OC

DO - 10.1164/rccm.201302-0247OC

M3 - Article

C2 - 23947473

VL - 188

SP - 948

EP - 957

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 8

ER -

TESRA and ECLIPSE Investigators, Cheng DT, Kim DK, Cockayne DA, Belousov A, Bitter H et al. Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 2013 Oct 15;188(8):948-57. https://doi.org/10.1164/rccm.201302-0247OC

Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease

Abstract

Keywords

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PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY

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