Systems biological approach to Parkinson's disease: Uncovering effects of PD on the synapse

K.F. Heil, O. Sorokina, J. D. Armstrong, J Hellgren-kotaleski

Research output: Contribution to conferenceAbstractpeer-review

Abstract / Description of output

Traditional models of Parkinson’s disease (PD) focus on events at the neuronal synapse and although recently, non-synaptic pathways have been linked to PD, most therapies still target the synapse. Large-scale Genome Wide Association Studies (GWAS), mRNA array analyses and neuronal proteomics give new insights into causal and pathological mechanisms at all levels: genes – transcripts – proteins. Here we examined correlations amongst different datasets, specifically looking for evidence of synaptic mechanisms involved in PD.
Original languageEnglish
Publication statusPublished - 19 Jun 2016
Event20th International Congress of Parkinson's Disease and Movement Disorders - Berlin, Germany
Duration: 19 Jun 201623 Jun 2016

Conference

Conference20th International Congress of Parkinson's Disease and Movement Disorders
Country/TerritoryGermany
Period19/06/1623/06/16

Keywords / Materials (for Non-textual outputs)

  • Multidisciplinary Approach

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