Systems biological approach to Parkinson's disease: Uncovering effects of PD on the synapse

K.F. Heil; O. Sorokina; J. D. Armstrong; J Hellgren-kotaleski

Systems biological approach to Parkinson's disease: Uncovering effects of PD on the synapse

K.F. Heil, O. Sorokina, J. D. Armstrong, J Hellgren-kotaleski

Research output: Contribution to conference › Abstract › peer-review

Abstract

Traditional models of Parkinson’s disease (PD) focus on events at the neuronal synapse and although recently, non-synaptic pathways have been linked to PD, most therapies still target the synapse. Large-scale Genome Wide Association Studies (GWAS), mRNA array analyses and neuronal proteomics give new insights into causal and pathological mechanisms at all levels: genes – transcripts – proteins. Here we examined correlations amongst different datasets, specifically looking for evidence of synaptic mechanisms involved in PD.

Original language	English
Publication status	Published - 19 Jun 2016
Event	20th International Congress of Parkinson's Disease and Movement Disorders - Berlin, Germany Duration: 19 Jun 2016 → 23 Jun 2016

Conference

Conference	20th International Congress of Parkinson's Disease and Movement Disorders
Country/Territory	Germany
Period	19/06/16 → 23/06/16

Keywords / Materials (for Non-textual outputs)

Multidisciplinary Approach

Cite this

@conference{a58a4fa4eb5a4d9f93dad190b123cabe,

title = "Systems biological approach to Parkinson's disease: Uncovering effects of PD on the synapse",

abstract = "Traditional models of Parkinson{\textquoteright}s disease (PD) focus on events at the neuronal synapse and although recently, non-synaptic pathways have been linked to PD, most therapies still target the synapse. Large-scale Genome Wide Association Studies (GWAS), mRNA array analyses and neuronal proteomics give new insights into causal and pathological mechanisms at all levels: genes – transcripts – proteins. Here we examined correlations amongst different datasets, specifically looking for evidence of synaptic mechanisms involved in PD.",

keywords = "Multidisciplinary Approach",

author = "K.F. Heil and O. Sorokina and Armstrong, \{J. D.\} and J Hellgren-kotaleski",

note = "To cite this abstract in AMA style [abstract]. Mov Disord. 2016; 31 (suppl 2); 20th International Congress of Parkinson's Disease and Movement Disorders ; Conference date: 19-06-2016 Through 23-06-2016",

year = "2016",

month = jun,

day = "19",

language = "English",

}

TY - CONF

T1 - Systems biological approach to Parkinson's disease

T2 - 20th International Congress of Parkinson's Disease and Movement Disorders

AU - Heil, K.F.

AU - Sorokina, O.

AU - Armstrong, J. D.

AU - Hellgren-kotaleski, J

N1 - To cite this abstract in AMA style [abstract]. Mov Disord. 2016; 31 (suppl 2)

PY - 2016/6/19

Y1 - 2016/6/19

N2 - Traditional models of Parkinson’s disease (PD) focus on events at the neuronal synapse and although recently, non-synaptic pathways have been linked to PD, most therapies still target the synapse. Large-scale Genome Wide Association Studies (GWAS), mRNA array analyses and neuronal proteomics give new insights into causal and pathological mechanisms at all levels: genes – transcripts – proteins. Here we examined correlations amongst different datasets, specifically looking for evidence of synaptic mechanisms involved in PD.

AB - Traditional models of Parkinson’s disease (PD) focus on events at the neuronal synapse and although recently, non-synaptic pathways have been linked to PD, most therapies still target the synapse. Large-scale Genome Wide Association Studies (GWAS), mRNA array analyses and neuronal proteomics give new insights into causal and pathological mechanisms at all levels: genes – transcripts – proteins. Here we examined correlations amongst different datasets, specifically looking for evidence of synaptic mechanisms involved in PD.

KW - Multidisciplinary Approach

UR - http://www.mdsabstracts.org/abstract/systems-biological-approach-to-parkinsons-disease-uncovering-effects-of-pd-on-the-synapse/

M3 - Abstract

Y2 - 19 June 2016 through 23 June 2016

ER -

Systems biological approach to Parkinson's disease: Uncovering effects of PD on the synapse

Abstract

Conference

Keywords / Materials (for Non-textual outputs)

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