Systems biology approaches applied to regenerative medicine

Laura E McNamara, Lesley-Anne Turner, Karl V Burgess

Research output: Contribution to journalArticlepeer-review

Abstract

Systems biology is the creation of theoretical and mathematical models for the study of biological systems, as an engine for hypothesis generation and to provide context to experimental data. It is underpinned by the collection and analysis of complex datasets from different biological systems, including global gene, RNA, protein and metabolite profiles. Regenerative medicine seeks to replace or repair tissues with compromised function (for example, through injury, deficiency or pathology), in order to improve their functionality. In this paper, we will address the application of systems biology approaches to the study of regenerative medicine, with a particular focus on approaches to study modifications to the genome, transcripts and small RNAs, proteins and metabolites.
Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalCurrent Pathobiology Reports
Volume3
Issue number1
DOIs
Publication statusPublished - 10 Feb 2015

Keywords

  • systems biology
  • epigenomics
  • transcriptomics
  • proteomics
  • metabolomics
  • regenerative medicine

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