T-2-Weighted STIR Imaging of Myocardial Edema Associated With Ischemia-Reperfusion Injury: The Influence of Proton Density Effect on Image Contrast

Xiangzhi Zhou, Veronica Rundell, Ying Liu, Richard Tang, Rachel Klein, Saurabh Shah, Sven Zuehlsdorff, Sotirios A. Tsaftaris, Debiao Li, Rohan Dharmakumar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To investigate the contribution of proton density (PD) in T-2-STIR based edema imaging in the setting of acute myocardial infarction (AMI).

Materials and Methods: Canines (n = 5), subjected to full occlusion of the left anterior descending artery for 3 hours, underwent serial magnetic resonance imaging (MRI) studies 2 hours postreperfusion (day 0) and on day 2. During each study, T-1 and T-2 maps, STIR (TE = 7.1 msec and 64 msec) and late gadolinium enhancement (LGE) images were acquired. Using T-1 and T-2 maps, relaxation and PD contributions to myocardial edema contrast (EC) in STIR images at both TEs were calculated.

Results: Edematous territories showed significant increase in PD (20.3 +/- 14.3%, P <0.05) relative to healthy territories. The contributions of T-1 changes and T-2 or PD changes toward EC were in opposite directions. One-tailed t-test confirmed that the mean T-2 and PD-based EC at both TEs were greater than zero. EC from STIR images at TE = 7.1 msec was dominated by PD than T-2 effects (94.3 +/- 11.3% vs. 17.6 +/- 2.5%, P <0.05), while at TE 64 msec, T-2 effects were significantly greater than PD effects (90.8 +/- 20.3% vs. 12.5 +/- 11.9%, P <0.05). The contribution from PD in standard STIR acquisitions (TE 64 msec) was significantly higher than 0 (P <0.05).

Conclusion: In addition to T-2-weighting, edema detection in the setting of AMI with T-2-weighted STIR imaging has a substantial contribution from PD changes, likely stemming from increased free-water content within the affected tissue. This suggests that imaging approaches that take advantage of both PD as well as T-2 effects may provide the optimal sensitivity for detecting myocardial edema.

Original languageEnglish
Pages (from-to)962-967
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume33
Issue number4
DOIs
Publication statusPublished - Apr 2011

Keywords

  • T-2-STIR
  • myocardial edema
  • proton density
  • ischemia-reperfusion injury
  • CARDIOVASCULAR MAGNETIC-RESONANCE
  • INFARCTION
  • HEART
  • BLOOD
  • SSFP

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