T cell-macrophage interaction in arginase-mediated resistance to herpes simplex virus

L Bonina, Anthony Nash, A Arena, K.N Leung, P Wildy

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Peritoneal macrophages activated by-products derived from a herpes simplex virus-specific helper T cell clone were used to investigate intrinsic and extrinsic resistance mechanisms to herpes simplex virus type 1 infection in vitro. T cell-activated macrophages produced fewer infective centres, indicating enhanced intrinsic resistance, and markedly reduced the growth of virus in a permissive cell line. The reduction in virus growth correlated with the depletion of arginine in the support medium, presumably resulting from increased arginase production by activated macrophages. The significance of these findings for antiviral immunity in vivo is discussed.
Original languageEnglish
Pages (from-to)501-5
Number of pages5
JournalVirus Research
Volume1
Issue number6
Publication statusPublished - Sept 1984

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Arginase/pharmacology
  • Herpes Simplex/immunology
  • Macrophages/immunology
  • Mice
  • Mice, Inbred BALB C
  • T-Lymphocytes/immunology

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