T cell-macrophage interactions in the immune response to herpes simplex virus: the significance of interferon-gamma

J.M Seid, M. Liberto, L Bonina, K.N Leung, Anthony Nash

Research output: Contribution to journalArticlepeer-review

Abstract

The antiviral properties of a herpex simplex virus type 1-specific 'helper' T cell clone were investigated. The clone was found to be deficient in interleukin 2 production, although it produced interleukin 3 and interferon-gamma upon stimulation with the virus in vitro. Supernatants containing these lymphokines were observed to increase the virocidal activity of macrophages in vitro and furthermore induced these cells to mediate cytotoxic activity against virus-infected target cells. Macrophage activation was linked to the presence of interferon-gamma in the clone supernatant. The implications of these results for protection against this virus in vivo are discussed.
Original languageEnglish
Pages (from-to)2799-802
Number of pages4
JournalJournal of General Virology
Volume67
Issue number12
DOIs
Publication statusPublished - Dec 1986

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