TY - JOUR
T1 - T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice
AU - Meyer-Luehmann, Melanie
AU - Mora, J Rodrigo
AU - Mielke, Matthew
AU - Spires-Jones, Tara L
AU - de Calignon, Alix
AU - von Andrian, Ulrich H
AU - Hyman, Bradley T
PY - 2011
Y1 - 2011
N2 - Immunization against amyloid-β (Aβ), the peptide that accumulates in the form of senile plaques and in the cerebrovasculature in Alzheimer's disease (AD), causes a dramatic immune response that prevents plaque formation and clears accumulated Aβ in transgenic mice. In a clinical trial of Aβ immunization, some patients developed meningoencephalitis and hemorrhages. Neuropathological investigations of patients who died after the trial showed clearance of amyloid pathology, but also a powerful immune response involving activated T cells probably underlying the negative effects of the immunization.
AB - Immunization against amyloid-β (Aβ), the peptide that accumulates in the form of senile plaques and in the cerebrovasculature in Alzheimer's disease (AD), causes a dramatic immune response that prevents plaque formation and clears accumulated Aβ in transgenic mice. In a clinical trial of Aβ immunization, some patients developed meningoencephalitis and hemorrhages. Neuropathological investigations of patients who died after the trial showed clearance of amyloid pathology, but also a powerful immune response involving activated T cells probably underlying the negative effects of the immunization.
U2 - 10.1186/1750-1326-6-22
DO - 10.1186/1750-1326-6-22
M3 - Article
C2 - 21388539
SN - 1750-1326
VL - 6
SP - 22
JO - Molecular Neurodegeneration
JF - Molecular Neurodegeneration
ER -