T-helper 1, T-helper 2 and immunosuppressive cytokines in canine atopic dermatitis

T J Nuttall, P A Knight, S M McAleese, J R Lamb, P B Hill

Research output: Contribution to journalArticlepeer-review


Atopic dermatitis is a common inflammatory skin disease of humans and dogs. Human atopic dermatitis is associated with T-helper (Th) 2 type responses, although Th1 cytokines are present in chronic lesions. This study used semi-quantitative reverse transcriptase polymerase chain reactions to determine the expression of gene transcripts for immunosuppressive cytokines (transforming growth factor beta [TGFbeta] and interleukin [IL]-10), Th2 type cytokines (IL-4 and IL-6) and Th1 type cytokines (interferon gamma [IFNgamma], tumour necrosis factor alpha [TNFalpha], IL-2 and IL-12) in lesional atopic, non-lesional atopic and healthy canine skin. Canine atopic dermatitis was associated with over-expression of IL-4 mRNA and reduced transcription of TGFbeta compared to healthy skin (ANOVA, p
Original languageEnglish
Pages (from-to)379-84
Number of pages6
JournalVeterinary Immunology and Immunopathology
Issue number3-4
Publication statusPublished - 10 Sep 2002


  • Animals
  • Cytokines
  • Dermatitis, Atopic
  • Dog Diseases
  • Dogs
  • Interleukin-2
  • Interleukin-4
  • RNA, Messenger
  • Reverse Transcriptase Polymerase Chain Reaction
  • Th1 Cells
  • Th2 Cells
  • Transforming Growth Factor beta


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