T-helper 1, T-helper 2 and immunosuppressive cytokines in canine atopic dermatitis

T J Nuttall; P A Knight; S M McAleese; J R Lamb; P B Hill

doi:10.1016/S0165-2427(02)00076-4

T-helper 1, T-helper 2 and immunosuppressive cytokines in canine atopic dermatitis

T J Nuttall, P A Knight, S M McAleese, J R Lamb, P B Hill

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Atopic dermatitis is a common inflammatory skin disease of humans and dogs. Human atopic dermatitis is associated with T-helper (Th) 2 type responses, although Th1 cytokines are present in chronic lesions. This study used semi-quantitative reverse transcriptase polymerase chain reactions to determine the expression of gene transcripts for immunosuppressive cytokines (transforming growth factor beta [TGFbeta] and interleukin [IL]-10), Th2 type cytokines (IL-4 and IL-6) and Th1 type cytokines (interferon gamma [IFNgamma], tumour necrosis factor alpha [TNFalpha], IL-2 and IL-12) in lesional atopic, non-lesional atopic and healthy canine skin. Canine atopic dermatitis was associated with over-expression of IL-4 mRNA and reduced transcription of TGFbeta compared to healthy skin (ANOVA, p

Original language	English
Pages (from-to)	379-84
Number of pages	6
Journal	Veterinary Immunology and Immunopathology
Volume	87
Issue number	3-4
DOIs	https://doi.org/10.1016/S0165-2427(02)00076-4
Publication status	Published - 10 Sep 2002

Keywords

Animals
Cytokines
Dermatitis, Atopic
Dog Diseases
Dogs
Interleukin-2
Interleukin-4
RNA, Messenger
Reverse Transcriptase Polymerase Chain Reaction
Th1 Cells
Th2 Cells
Transforming Growth Factor beta

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title = "T-helper 1, T-helper 2 and immunosuppressive cytokines in canine atopic dermatitis",

abstract = "Atopic dermatitis is a common inflammatory skin disease of humans and dogs. Human atopic dermatitis is associated with T-helper (Th) 2 type responses, although Th1 cytokines are present in chronic lesions. This study used semi-quantitative reverse transcriptase polymerase chain reactions to determine the expression of gene transcripts for immunosuppressive cytokines (transforming growth factor beta [TGFbeta] and interleukin [IL]-10), Th2 type cytokines (IL-4 and IL-6) and Th1 type cytokines (interferon gamma [IFNgamma], tumour necrosis factor alpha [TNFalpha], IL-2 and IL-12) in lesional atopic, non-lesional atopic and healthy canine skin. Canine atopic dermatitis was associated with over-expression of IL-4 mRNA and reduced transcription of TGFbeta compared to healthy skin (ANOVA, p",

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AU - Nuttall, T J

AU - Knight, P A

AU - McAleese, S M

AU - Lamb, J R

AU - Hill, P B

PY - 2002/9/10

Y1 - 2002/9/10

N2 - Atopic dermatitis is a common inflammatory skin disease of humans and dogs. Human atopic dermatitis is associated with T-helper (Th) 2 type responses, although Th1 cytokines are present in chronic lesions. This study used semi-quantitative reverse transcriptase polymerase chain reactions to determine the expression of gene transcripts for immunosuppressive cytokines (transforming growth factor beta [TGFbeta] and interleukin [IL]-10), Th2 type cytokines (IL-4 and IL-6) and Th1 type cytokines (interferon gamma [IFNgamma], tumour necrosis factor alpha [TNFalpha], IL-2 and IL-12) in lesional atopic, non-lesional atopic and healthy canine skin. Canine atopic dermatitis was associated with over-expression of IL-4 mRNA and reduced transcription of TGFbeta compared to healthy skin (ANOVA, p

AB - Atopic dermatitis is a common inflammatory skin disease of humans and dogs. Human atopic dermatitis is associated with T-helper (Th) 2 type responses, although Th1 cytokines are present in chronic lesions. This study used semi-quantitative reverse transcriptase polymerase chain reactions to determine the expression of gene transcripts for immunosuppressive cytokines (transforming growth factor beta [TGFbeta] and interleukin [IL]-10), Th2 type cytokines (IL-4 and IL-6) and Th1 type cytokines (interferon gamma [IFNgamma], tumour necrosis factor alpha [TNFalpha], IL-2 and IL-12) in lesional atopic, non-lesional atopic and healthy canine skin. Canine atopic dermatitis was associated with over-expression of IL-4 mRNA and reduced transcription of TGFbeta compared to healthy skin (ANOVA, p

KW - Animals

KW - Cytokines

KW - Dermatitis, Atopic

KW - Dog Diseases

KW - Dogs

KW - Interleukin-2

KW - Interleukin-4

KW - RNA, Messenger

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Th1 Cells

KW - Th2 Cells

KW - Transforming Growth Factor beta

U2 - 10.1016/S0165-2427(02)00076-4

DO - 10.1016/S0165-2427(02)00076-4

M3 - Article

C2 - 12072261

VL - 87

SP - 379

EP - 384

JO - Veterinary Immunology and Immunopathology

JF - Veterinary Immunology and Immunopathology

SN - 0165-2427

IS - 3-4

ER -

T-helper 1, T-helper 2 and immunosuppressive cytokines in canine atopic dermatitis

Abstract

Keywords

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