TADDOL-Derived Phosphonites, Phosphites, and Phosphoramidites in Asymmetric Catalysis

Hon Wai Lam

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

In metal-based asymmetric catalysis, desirable attributes for chiral ligands include low cost, simplicity of synthesis, and ease of variation to enable fine-tuning of a particular transformation. TADDOL-derived phosphonites, phosphites, and phosphoramidites constitute one family of chiral ligand that possesses these features. In recent times, these ligands have excelled in a wide range of catalytic asymmetric reactions. This review article summarizes progress in this area.

Original languageEnglish
Pages (from-to)2011-2043
Number of pages33
JournalSynthesis: Journal of Synthetic Organic Chemistry
Issue number13
DOIs
Publication statusPublished - Jul 2011

Keywords

  • asymmetric catalysis
  • phosphorus
  • ligands
  • enantioselectivity
  • TADDOL
  • ENANTIOSELECTIVE CONJUGATE ADDITION
  • SILICON-STEREOGENIC SILANES
  • CHIRAL PHOSPHORUS LIGANDS
  • CYCLIC MESO-ANHYDRIDES
  • H BOND ACTIVATION
  • ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS
  • DONOR-FUNCTIONALIZED ALCOHOLS
  • KINETIC RESOLUTION
  • DIALKYLZINC REAGENTS
  • REDUCTIVE ALDOL

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