Tamoxifen induced apoptosis in ZR-75 breast cancer xenografts antedates tumour regression

D A Cameron, A A Ritchie, S Langdon, T J Anderson, W R Miller

Research output: Contribution to journalArticlepeer-review

Abstract

The ZR-75-1 ER positive breast cancer cell line, xenografted in female nude mice, has been used to determine the effect of tamoxifen on cell proliferation (as measured by mitosis) and cell death (as evidenced by apoptosis and necrosis). After 2 days treatment, there was a significant rise in apoptosis (p
Original languageEnglish
Pages (from-to)99-107
Number of pages9
JournalBreast cancer research and treatment
Volume45
Issue number2
Publication statusPublished - Sep 1997

Keywords

  • Animals
  • Antineoplastic Agents, Hormonal
  • Apoptosis
  • Breast Neoplasms
  • Cell Division
  • Female
  • Mice
  • Mice, Nude
  • Mitotic Index
  • Neoplasm Transplantation
  • Tamoxifen
  • Time Factors
  • Transplantation, Heterologous
  • Tumor Cells, Cultured

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