Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD

Baljit K Ubhi; Kian Kai Cheng; Jiyang Dong; Tobias Janowitz; Duncan Jodrell; Ruth Tal-Singer; William MacNee; David A Lomas; John H Riley; Julian L Griffin; Susan C Connor

doi:10.1039/c2mb25194a

Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD

Baljit K Ubhi, Kian Kai Cheng, Jiyang Dong, Tobias Janowitz, Duncan Jodrell, Ruth Tal-Singer, William MacNee, David A Lomas, John H Riley, Julian L Griffin, Susan C Connor

Research output: Contribution to journal › Article › peer-review

Abstract

COPD, a leading cause of mortality is currently assessed by spirometry (forced expiratory volume in 1 second, FEV(1)). However FEV(1) does not correlate with patient mortality. ECLIPSE (Evaluation of Chronic obstructive pulmonary disease to Longitudinally Identify Predictive Surrogate Endpoints) aims to identify biomarkers that correlate with clinically relevant COPD subtypes, and to assess how these may predict disease progression. New methods were developed and validated to evaluate small molecules as potential diagnostic tools in patients with COPD, COPD related cachexia and cancer related cachexia.

Original language	English
Pages (from-to)	3125-33
Number of pages	9
Journal	Molecular BioSystems
Volume	8
Issue number	12
DOIs	https://doi.org/10.1039/c2mb25194a
Publication status	Published - 30 Oct 2012

Keywords / Materials (for Non-textual outputs)

Aged
Amino Acids
Biological Markers
Body Mass Index
Cachexia
Disease Progression
Female
Humans
Longitudinal Studies
Male
Metabolomics
Middle Aged
Pancreatic Neoplasms
Pulmonary Disease, Chronic Obstructive
Pulmonary Emphysema
Respiratory Function Tests
Severity of Illness Index
Smoking
Tandem Mass Spectrometry
gamma-Aminobutyric Acid

Access to Document

10.1039/c2mb25194a

PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY
Iredale, J. (Principal Investigator)
MRC
1/09/12 → 31/08/16
Project: Research

Cite this

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title = "Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD",

abstract = "COPD, a leading cause of mortality is currently assessed by spirometry (forced expiratory volume in 1 second, FEV(1)). However FEV(1) does not correlate with patient mortality. ECLIPSE (Evaluation of Chronic obstructive pulmonary disease to Longitudinally Identify Predictive Surrogate Endpoints) aims to identify biomarkers that correlate with clinically relevant COPD subtypes, and to assess how these may predict disease progression. New methods were developed and validated to evaluate small molecules as potential diagnostic tools in patients with COPD, COPD related cachexia and cancer related cachexia.",

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author = "Ubhi, {Baljit K} and Cheng, {Kian Kai} and Jiyang Dong and Tobias Janowitz and Duncan Jodrell and Ruth Tal-Singer and William MacNee and Lomas, {David A} and Riley, {John H} and Griffin, {Julian L} and Connor, {Susan C}",

year = "2012",

month = oct,

day = "30",

doi = "10.1039/c2mb25194a",

language = "English",

volume = "8",

pages = "3125--33",

journal = "Molecular BioSystems",

issn = "1742-2051",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD

AU - Ubhi, Baljit K

AU - Cheng, Kian Kai

AU - Dong, Jiyang

AU - Janowitz, Tobias

AU - Jodrell, Duncan

AU - Tal-Singer, Ruth

AU - MacNee, William

AU - Lomas, David A

AU - Riley, John H

AU - Griffin, Julian L

AU - Connor, Susan C

PY - 2012/10/30

Y1 - 2012/10/30

N2 - COPD, a leading cause of mortality is currently assessed by spirometry (forced expiratory volume in 1 second, FEV(1)). However FEV(1) does not correlate with patient mortality. ECLIPSE (Evaluation of Chronic obstructive pulmonary disease to Longitudinally Identify Predictive Surrogate Endpoints) aims to identify biomarkers that correlate with clinically relevant COPD subtypes, and to assess how these may predict disease progression. New methods were developed and validated to evaluate small molecules as potential diagnostic tools in patients with COPD, COPD related cachexia and cancer related cachexia.

AB - COPD, a leading cause of mortality is currently assessed by spirometry (forced expiratory volume in 1 second, FEV(1)). However FEV(1) does not correlate with patient mortality. ECLIPSE (Evaluation of Chronic obstructive pulmonary disease to Longitudinally Identify Predictive Surrogate Endpoints) aims to identify biomarkers that correlate with clinically relevant COPD subtypes, and to assess how these may predict disease progression. New methods were developed and validated to evaluate small molecules as potential diagnostic tools in patients with COPD, COPD related cachexia and cancer related cachexia.

KW - Aged

KW - Amino Acids

KW - Biological Markers

KW - Body Mass Index

KW - Cachexia

KW - Disease Progression

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Metabolomics

KW - Middle Aged

KW - Pancreatic Neoplasms

KW - Pulmonary Disease, Chronic Obstructive

KW - Pulmonary Emphysema

KW - Respiratory Function Tests

KW - Severity of Illness Index

KW - Smoking

KW - Tandem Mass Spectrometry

KW - gamma-Aminobutyric Acid

U2 - 10.1039/c2mb25194a

DO - 10.1039/c2mb25194a

M3 - Article

C2 - 23051772

SN - 1742-2051

VL - 8

SP - 3125

EP - 3133

JO - Molecular BioSystems

JF - Molecular BioSystems

IS - 12

ER -

Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD

Abstract

Keywords / Materials (for Non-textual outputs)

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PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY

Cite this