Targeting angiogenesis in the pathological ovary

W. Colin Duncan, Junko Nio-Kobayashi

Research output: Contribution to journalArticlepeer-review


The ovary is a key tissue in the study of physiological neo-vascularisation in the adult and its study has highlighted important molecules involved in the regulation of angiogenesis in vivo. These include vascular endothelial growth factor, delta-like ligand 4, thrombospondin-1, prokineticin-1 and prostaglandin E-2. Targeting these molecular pathways has therapeutic potential and their manipulation has an increasing preclinical and clinical role in the management of the pathological ovary. Targeting angiogenic pathways has utility in the promotion of ovarian angiogenesis to improve tissue and follicle survival and function as well as the prevention and management of ovarian hyperstimulation syndrome. There is a theoretical possibility that targeting angiogenesis may improve the function of the polycystic ovary and a real role for targeting angiogenesis in ovarian cancer.

Original languageEnglish
Pages (from-to)362-371
Number of pages10
JournalReproduction, Fertility and Development
Issue number2
Publication statusPublished - 2013


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