Methods: Individual patient data from 34 randomized exercise trials (n ¼4519) were pooled. Linear mixed-effect models were used to study moderator effects of baseline values on exercise intervention outcomes and to determine whether these moderator effects differed by intervention timing (during vs post-treatment). All statistical tests were two-sided.
Results: Moderator effects of baseline fatigue and PF were consistent across intervention timing, with greater effects inpatients with worse fatigue (Pinteraction ¼ .05) and worse PF (Pinteraction ¼ .003). Moderator effects of baseline aerobic fitness, muscle strength, and QoL differed by intervention timing. During treatment, effects on aerobic fitness were greater for patients with better baseline aerobic fitness (Pinteraction ¼ .002). Post-treatment, effects on upper (Pinteraction < .001) and lower (Pinteraction ¼ .01) body muscle strength and QoL (Pinteraction < .001) were greater in patients with worse baseline values.
Conclusion: Although exercise should be encouraged for most cancer patients during and post-treatments, targeting specific target patients with high fatigue and low PF. During treatment, patients experience benefit for muscle strength and QoL regardless of baseline values; however, only patients with low baseline values benefit post-treatment. For aerobic fitness, patients with low baseline values do not appear to benefit from exercise during treatment.
- quality of life
- baseline value
- muscle strength
- physical function