Projects per year
Abstract / Description of output
Proof-of-concept studies demonstrate that antimalarial drugs designed for human treatment can also be applied to mosquitoes to interrupt malaria transmission. Deploying a new control tool is ideally undertaken within a stewardship programme that maximises a drug's lifespan by minimising the risk of resistance evolution and slowing its spread once emerged. We ask: what are the epidemiological and evolutionary consequences of targeting parasites within mosquitoes. Our synthesis argues that targeting parasites inside mosquitoes (i) can be modelled by readily expanding existing epidemiological frameworks; (ii) provides a functionally novel control method that has potential to be more robust to resistance evolution than targeting parasites in humans; and (iii) could extend the lifespan and clinical benefit of antimalarials used exclusively to treat humans.
Keywords / Materials (for Non-textual outputs)
- drug resistance
- parasite-vector interactions
- within vector dynamics
FingerprintDive into the research topics of 'Targeting malaria parasites inside mosquitoes: Ecoevolutionary consequences'. Together they form a unique fingerprint.
1/11/16 → 30/09/23
14/03/19 → 30/12/22
1/10/18 → 30/06/22