Targeting malaria parasites inside mosquitoes: Ecoevolutionary consequences

Tsukushi Kamiya, Douglas G. Paton, Flaminia Catteruccia, Sarah E. Reece

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Proof-of-concept studies demonstrate that antimalarial drugs designed for human treatment can also be applied to mosquitoes to interrupt malaria transmission. Deploying a new control tool is ideally undertaken within a stewardship programme that maximises a drug's lifespan by minimising the risk of resistance evolution and slowing its spread once emerged. We ask: what are the epidemiological and evolutionary consequences of targeting parasites within mosquitoes. Our synthesis argues that targeting parasites inside mosquitoes (i) can be modelled by readily expanding existing epidemiological frameworks; (ii) provides a functionally novel control method that has potential to be more robust to resistance evolution than targeting parasites in humans; and (iii) could extend the lifespan and clinical benefit of antimalarials used exclusively to treat humans.
Original languageEnglish
Pages (from-to)1031-1040
Number of pages10
JournalTrends in Parasitology
Issue number12
Early online date5 Oct 2022
Publication statusPublished - 1 Dec 2022

Keywords / Materials (for Non-textual outputs)

  • drug resistance
  • transmission
  • parasite-vector interactions
  • within vector dynamics
  • epidemiology
  • sporogony


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