Targeting mediators of Wnt signalling pathways by GnRH in gonadotropes

Samantha Gardner, Emmanouil Stavrou, Patricia E Rischitor, Elena Faccenda, Adam J Pawson

Research output: Contribution to journalArticlepeer-review

Abstract

The binding of GnRH to its receptor on pituitary gonadotropes leads to the targeting of a diverse array of signalling mediators. These mediators drive multiple signal transduction pathways, which in turn regulate a variety of cellular processes, including the biosynthesis and secretion of the gonadotropins LH and FSH. Advances in our understanding of the mechanisms and signalling pathways that are recruited to regulate gonadotrope function are continually being made. This review will focus on the recent demonstration that key mediators of the canonical Wnt signalling pathway are targeted by GnRH in gonadotropes, and that these may play essential roles in regulating the expression of many of the key players in gonadotrope biology, including the GnRH receptor and the gonadotropins.
Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalJournal of molecular endocrinology
Volume44
Issue number4
DOIs
Publication statusPublished - 2010

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