Targets downstream of Cdk8 in Dictyostelium development

David M Greene, Gareth Bloomfield, Jason Skelton, Alasdair Ivens, Catherine J Pears

Research output: Contribution to journalArticlepeer-review

Abstract

Cdk8 is a component of the mediator complex which facilitates transcription by RNA polymerase II and has been shown to play an important role in development of Dictyostelium discoideum. This eukaryote feeds as single cells but starvation triggers the formation of a multicellular organism in response to extracellular pulses of cAMP and the eventual generation of spores. Strains in which the gene encoding Cdk8 have been disrupted fail to form multicellular aggregates unless supplied with exogenous pulses of cAMP and later in development, cdk8- cells show a defect in spore production.
Original languageEnglish
Article number2
JournalBMC Developmental Biology
Volume11
DOIs
Publication statusPublished - 2011

Keywords

  • Phenotype
  • NADH, NADPH Oxidoreductases
  • Gene Duplication
  • Cyclin-Dependent Kinase 8
  • Blotting, Northern
  • Proteomics
  • Microarray Analysis
  • Fatty Acid Synthetase Complex
  • Cyclic AMP-Dependent Protein Kinases
  • 4-Hydroxyphenylpyruvate Dioxygenase
  • Spores, Protozoan
  • Dictyostelium

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