We describe here the use of computational methods for evaluation of the low dose effects on human fibroblasts after irradiation with Technetium-99m (Tc-99m) Auger electrons. The results suggest a parabolic relationship between the irradiation of fibroblasts with Tc-99m Auger electrons and the total absorbed dose. Additionally, the results on very low absorbed doses may be explained by the bystander effect, which has been implicated on the cell's effects at low doses. Further in vitro evaluation will be worthwhile to clarify these findings. (C) 2010 Elsevier Ltd. All rights reserved.
- Targeted tumor radiotherapy
- Virtual cell radiobiology simulator
- Monte Carlo damage simulator
- TARGETED RADIOTHERAPY